Mental Nerve Neuropathy as a Manifestation of Systemic Malignancy

Česká verzia

Authors: Z. Ambler
Authors place of work: Neurologická klinika LF UK a FN Plzeň
Published in the journal: Cesk Slov Neurol N 2009; 72/105(6): 560-562
Category: Case Report

Summary

Mental nerve neuropathy (MNN) termed also as numb chin syndrome is a sensory neuropathy presenting with paresthesias and numbness of the chin, lower lip and gingival mucosa. Except local odontogenic causes MNN can be manifestation of systemic malignancy, mostly cancer of breast, prostate and hematological malignancies. The author reports a case of 41‑year- old male patient with MNN as an initial symptom of Burkitt‘s leukemia. The appearance of MNN should be considered as a significant symptom to detect a potential systemic malignancy.

Key words:
mental nerve neuropathy – numb chin syndrome – malignancy – leptomeningeal metastases

Zdroje

1. Kalladka M, Proter N, Benoliel R, Czerninski R, Eliav E. Mental nerve neuropathy: patient characteristics and neurosensory changes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106(3): 364– 370.

2. Sève P, Gachon E, Petiot P, Stankovic K, Charhon A, Broussolle C. Successful treatment with rituximab in a patient with mental nerve neuropathy in primary Sjögren‘s syndrome. Rheumatol Int 2007; 28(2): 175– 177.

3. Calverley JR, Mohnac AM. Syndrome of the numb chin. Arch Intern Med 1963; 112: 819– 821.

4. Furukawa T. Charles Bell‘s description of numb chin syndrome. Neurology 1988; 38: 331.

5. Lossos A, Siegal T. Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance. Neurology 1992; 42(6): 1181– 1184.

6. Galán Gil S, Peñarrocha Diago M, Peñarrocha Diago M. Malignant mental nerve neuropathy: systematic review. Med Oral Patol Oral Cir Bucal 2008; 13(10): E616– E621.

7. Martos- Díaz P, Bances- Del- Castillo R, Vidal- Laso R, Mancha- de- la- Plata M, Cho- Lee GY, Naval- Gías L. Bilateral Mental Nerve Neuropathy as the Sole Presenting Symptom of Burkitt‘s Lymphoma. Med Oral Patol Oral Cir Bucal 2009; 14(8): e408– e410.

8. Laurencet FM, Anchisi S, Tullen E, Dietrich PY. Mental neuropathy, report of five cases and review of the literature. Crit Rev Oncol Hematol 2000; 34(1): 71– 79.

9. Atienza MR, Garcia- Contreras R, Varela JM, Martin‑Garrido I, Gutierrez- Rivero S, Medrano FJ et al. Mental nerve neuropathy: report of two cases. Eur J Intern Med 2008; 19 (Suppl 1): S55– S58.

10. Smith SF, Blackman G, Hopper C. Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105(3): e53– e56.

11. Colella G, Giudice A, Siniscalchi G, Falcone U, Guastafierro S. Chin numbness: a symptom that should not be underestimated: a review of 12 cases. Am J Med Sci 2009; 337(6): 407– 410.