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Vascular Risk Factors and Alzheimer’s Disease


Authors: B. Urbanová 1;  A. Tomek 1;  R. Mikulík 2;  H. Magerová 1;  K. Sheardová 2;  D. Hořínek 3,4;  J. Hort 1,3
Authors place of work: Neurologická klinika 2. LF UK a FN v Motole, Praha 1;  Mezinárodní centrum klinického výzkumu (ICRC), Neurologická klinika FN u sv. Anny v Brně 2;  Mezinárodní centrum klinického výzkumu (ICRC), FN u sv. Anny v Brně 3;  Neurochirurgická klinika 1. LF UK a ÚVN Praha 4
Published in the journal: Cesk Slov Neurol N 2012; 75/108(6): 694-699
Category: Review Article

Summary

In this paper, we summarize current knowledge on the impact of vascular brain changes and vascular risk factors on the development and course of Alzheimer’s disease. The authors discuss the time relation and interactions between vascular and neurohistopathological changes typical for Alzheimer’s disease, commenting on possible underlying mechanisms of their origin. Neuroimaging methods to detect vascular changes in the brain are described; findings of these methods are correlated with an impact on cognitive functions and on the risk of developing Alzheimer’s disease reported in the literature. The most common structural changes associated with vascular pathology are white matter lesions and cerebral micro­bleeds detectable on MRI. Perfusion SPECT and neurosonology monitor functional changes in cerebral perfusion. Detailed description of vascular changes in patients with Alzheimer’s disease could become a significant parameter in predicting the disease progression in patients with mild cognitive impairment or incipient dementia and assist in determining the risk of dementia in asymptomatic seniors. Neurosonology, an inexpensive, readily available and non-invasive examination of vascular parameters, is a promising monitoring method.

Key words:
Alzheimer’s disease – vascular hypothesis – vascular risk factors – white matter lesions – microbleeds – neurosonology


Zdroje

1. Ressner P, Hort J, Rektorová I, Rusina R, Línek V, Sheardová K. Doporučené postupy pro diagnostiku Alzheimerovy nemoci a dalších onemocnění spojených s demencí. Cesk Slov Neurol N 2008; 71/104(4): 494–501.

2. Sheardová K, Hort J, Rusina R, Bartoš A, Línek V, Ressner P et al. Doporučené postupy pro terapii Alzheimerovy nemoci a ostatních demencí. Neurologie Praxi 2009; 10(1): 28–31.

3. Goedert M. Oskar Fischer and the study of dementia. Brain 2009; 132(Pt 4): 1102–1111.

4. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6(8): 734–746.

5. Hort J, Glosová L, Vyhnálek M, Bojar M, Škoda D, Hladíková M. Tau protein a beta amyloid v likvoru u Alzheimerovy choroby. Cesk Slov Neurol N 2007; 70/103(1): 30–36.

6. Hort J, O’Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I et al. EFNS guidelines for the diagnosis and management of Alzheimer’s disease. Eur J Neurol 2010; 17(10): 1236–1248.

7. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011; 7(3): 263–269.

8. Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH et al. Vascular dementia: dia­gnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993; 43(2): 250–260.

9. de la Torre JC, Mussivand T. Can disturbed brain microcirculation cause Alzheimer’s disease? Neurol Res 1993; 15(3): 146–153.

10. de la Torre JC. The vascular hypothesis of Alzheimer’s disease: bench to bedside and beyond. Neurodegener Dis 2010; 7(1–3): 116–121.

11. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997; 277(10): 813–817.

12. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347(9009): 1141–1145.

13. McGuinness B, Todd S, Passmore P, Bullock R. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. Cochrane Database Syst Rev 2009; 4: CD004034.

14. Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B et al. SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21(5): 875–886.

15. Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S et al. PROGRESS Collaborative Group. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003; 163(9): 1069–1075.

16. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265(24): 3255–3264.

17. Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council’s trial of hypertension in older adults. BMJ 1996; 312(7034): 801–815.

18. Forette F, Seux ML, Staessen JA, Thijs L, Birkenhäger WH, Babarskiene MR et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998; 352(9137): 1347–1351.

19. Breteler MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging 2000; 21(2): 153–160.

20. Sakka P, Tsolaki M, Hort J, Hager K, Soininen H, López Pousa S et al. Effectiveness of open-label donepezil treatment in patients with Alzheimer’s disease discontinuing memantine monotherapy. Curr Med Res Opin 2007; 23(12): 3153–3165.

21. Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C et al. HYVET investigators. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 2008; 7(8): 683–689.

22. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999; 53(9): 1937–1942.

23. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes? J Alzheimers Dis 2005; 7(1): 63–80.

24. Baker LD, Cross DJ, Minoshima S, Belongia D, Watson GS, Craft S. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 2011; 68(1): 51–57.

25. Sasaki N, Fukatsu R, Tsuzuki K, Hayashi Y, Yoshida T, Fujii N et al. Advanced glycation end products in Alzheimer’s disease and other neurodegenerative diseases. Am J Pathol 1998; 153(4): 1149–1155.

26. Tzimopoulou S, Cunningham VJ, Nichols TE, Searle G, Bird NP, Mistry P et al. A multi-center randomized proof-of-concept clinical trial applying [1F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer’s disease. J Alzheimers Dis 2010; 22(4): 1241–1256.

27. Gold M, Alderton C, Zvartau-Hind M, Egginton S, Saunders AM, Irizarry M et al. Rosiglitazone monotherapy in mild-to-moderate Alzheimer’s disease: results from a randomized, double-blind, placebo-controlled phase III study. Dement Geriatr Cogn Disord 2010; 30(2): 131–146.

28. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M et al. ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358(24): 2560–2572.

29. Notkola IL, Sulkava R, Pekkanen J, Erkinjuntti T, Ehnholm C, Kivinen P et al. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer’s disease. Neuroepidemiology 1998; 17(1): 14–20.

30. van Bockxmeer FM, Mamotte CD. Apolipoprotein epsilon 4 homozygosity in young men with coronary heart disease. Lancet 1992; 340(8824): 879–880.

31. Brouwers N, Sleegers K, van Broeckhoven C. Molecular genetics of Alzheimer’s disease: an update. Ann Med 2008; 40(8): 562–583.

32. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360(9326): 7–22.

33. Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM et al. PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002; 360(9346): 1623–1630.

34. McGuinness B, O’Hare J, Craig D, Bullock R, Malouf R, Passmore P. Statins for the treatment of dementia. Cochrane Database Syst Rev 2010; 8: CD007514.

35. Clarke C, Howard R, Rossor M, Shorvon S. Neurology: a Queen Square textbook. 1st ed. Oxford: Blackwell Publishing Ltd 2009.

36. DeCarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R et al. Measures of brain morphology and infarction in the Framingham heart study: establishing what is normal. Neurobiol Aging 2005; 26(4): 491–510.

37. Christiansen P, Larsson HB, Thomsen C, Wieslander SB, Henriksen O. Age dependent white matter lesions and brain volume changes in healthy volunteers. Acta Radiol 1994; 35(2): 117–122.

38. Scheltens P, Erkinjunti T, Leys D, Wahlund LO, Inzitari D, del Ser T et al. White matter changes on CT and MRI: an overview of visual rating scales. European Task Force on Age-Related White Matter Changes. Eur Neurol 1998; 39(2): 80–89.

39. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 1987; 149(2): 351–356.

40. Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994; 44(7): 1246–1252

41. DeCarli C, Miller BL, Swan GE, Reed T, Wolf PA, Carmelli D. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol 2001; 58(4): 643–647.

42. Wu CC, Mungas D, Petkov CI, Eberling JL, Zrelak PA, Buonocore MH et al. Brain structure and cognition in a community sample of elderly Latinos. Neurology 2002; 59(3): 383–391.

43. Wolf H, Ecke GM, Bettin S, Dietrich J, Gertz HJ. Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal study. Int J Geriatr Psychiatry 2000; 15(9): 803–812.

44. Lopez OL, Jagust WJ, Dulberg C, Becker JT, DeKosky ST, Fitzpatrick A et al. Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2. Arch Neurol 2003; 60(10): 1394–1399.

45. Magerová H, Vyhnálek M, Laczó J, Bojar M, Hort J. Přínos vyšetření čichu v časné diagnostice demencí neurodegenerativní etiologie. Cesk Slov Neurol N 2008; 71/104(3): 298–302.

46. De Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J et al. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 2002; 125(4): 765–772.

47. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study. Neurology 2001; 56(11): 1539–1545.

48. Ylikoski R, Ylikoski A, Erkinjuntti T, Sulkava R, Raininko R, Tilvis R. White matter changes in healthy elderly persons correlate with attention and speed of mental processing. Arch Neurol 1993; 50(8): 818–824.

49. Mirsen TR, Lee DH, Wong CJ, Diaz JF, Fox AJ, Hachinski VC et al. Clinical correlates of white-matter changes on magnetic resonance imaging scans of the brain. Arch Neurol 1991; 48(10): 1015–1021.

50. Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM et al. Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 2006; 67(12): 2192–2198.

51. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 1999; 20(4): 637–642.

52. Nakata Y, Shiga K, Yoshikawa K, Mizuno T, Mori S, Yamada K et al. Subclinical brain hemorrhages in Alzheimer’s disease: evaluation by magnetic resonance T2*-weighted images. Ann N Y Acad Sci 2002; 977: 169–172.

53. Hanyu H, Tanaka Y, Shimizu S, Takasaki M, Abe K. Cerebral microbleeds in Alzheimer’s disease. J Neurol 2003; 250(12): 1496–1497.

54. Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P. Prevalence and severity of microbleeds in a memory clinic setting. Neurology 2006; 66(9): 1356–1360.

55. Pettersen JA, Sathiyamoorthy G, Gao FQ, Szilagyi G, Nadkarni NK, St George-Hyslop P et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 2008; 65(6): 790–795.

56. Kalaria RN, Ballard C. Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 1999; 13 (Suppl 3): S115–S123.

57. Cordonnier C, van der Flier WM. Brain microbleeds and Alzheimer’s disease: innocent observation or key player? Brain 2011; 134(2): 335–344.

58. Vernooij MW, van der Lugt A, Ikram MA, Wie­lopolski PA, Niessen WJ, Hofman A et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008; 70(14): 1208–1214.

59. Goos JD, Kester MI, Barkhof F, Klein M, Blankenstein MA, Scheltens P et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 2009; 40(11): 3455–3460.

60. Kirsch W, McAuley G, Holshouser B, Petersen F, Ayaz M, Vinters HV et al. Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia. J Alzheimers Dis 2009; 17(3): 599–609.

61. DeKosky ST, Shih WJ, Schmitt FA, Coupal J, Kirkpatrick C. Assessing utility of single photon emission computed tomography (SPECT) scan in Alzheimer disease: correlation with cognitive severity. Alzheimer Dis Assoc Disord 1990; 4(1): 14–23.

62. Jobst KA, Barnetson LP, Shepstone BJ. Accurate prediction of histologically confirmed Alzheimer’s disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria, SPECT, X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memory and Aging. Int Psychogeriatr 1998; 10(3): 271–302.

63. Johnson KA, Lopera F, Jones K, Becker A, Sperling R, Hilson J et al. Presenilin-1-associated abnormalities in regional cerebral perfusion. Neurology 2001; 56(11): 1545–1551.

64. Johnson KA, Jones K, Holman BL, Becker JA, Spiers PA, Satlin A et al. Preclinical prediction of Alzheimer’s disease using SPECT. Neurology 1998; 50(6): 1563–1571.

65. Kogure D, Matsuda H, Ohnishi T, Asada T, Uno M, Kunihiro T et al. Longitudinal evaluation of early Alzheimer’s disease using brain perfusion SPECT. J Nucl Med 2000; 41(7): 1155–1162.

66. Johnson KA, Albert MS. Perfusion abnormalities in prodromal AD. Neurobiol Aging 2000; 21(2): 289–292.

67. Arikuni T, Sako H, Murata A. Ipsilateral connec­tions of the anterior cingulate cortex with the frontal and medial temporal cortices in the macaque monkey. Neurosci Res 1994; 21(1): 19–39.

68. Meguro K, Blaizot X, Kondoh Y, Le Mestric C, Baron JC, Chavoix C. Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET. Implications for Alzheimer’s disease. Brain 1999; 122(Pt 8): 1519–1531.

69. Peisker T, Bartos A, Skoda O, Ibrahim I, Kalvach P. Impact of aging on cerebral vasoregulation and parenchymal integrity. J Neurol Sci 2010; 299(1–2): 112–115.

70. Stefani A, Sancesario G, Pierantozzi M, Leone G, Galati S, Hainsworth AH et al. CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer’s and mixed dementia. J Neurol Sci 2009; 283(1–2): 109–115.

71. Bär KJ, Boettger MK, Seidler N, Mentzel HJ, Terborg C, Sauer H. Influence of galantamine on vasomotor reactivity in Alzheimer’s disease and vascular dementia due to cerebral microangiopathy. Stroke 2007; 38(12): 3186–3192.

72. Claassen JA, Diaz-Arrastia R, Martin-Cook K, Levine BD, Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. J Alzheimers Dis 2009; 17(3): 621–629.

73. Asil T, Uzuner N. Differentiation of vascular dementia and Alzheimer disease: a functional transcranial Doppler ultrasonographic study. J Ultrasound Med 2005; 24(8): 1065–1070.

74. Silvestrini M, Pasqualetti P, Baruffaldi R, Bartolini M, Handouk Y, Matteis M et al. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 2006; 37(4): 1010–1015.

75. Purandare N, Burns A, Daly KJ, Hardicre J, Morris J, Macfarlane G et al. Cerebral emboli as a potential cause of Alzheimer’s disease and vascular dementia: case-control study. BMJ 2006; 332(7550): 1119–1124.

76. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96(5): 1432–1437.

77. Hofman A, Ott A, Breteler MM, Bots ML, Slooter AJ, van Harskamp F et al. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer’s disease in the Rotterdam Study. Lancet 1997; 349(9046): 151–154.

78. Silvestrini M, Gobbi B, Pasqualetti P, Bartolini M, Baruffaldi R, Lanciotti C et al. Carotid atherosclerosis and cognitive decline in patients with Alzheimer’s disease. Neurobiol Aging 2009; 30(8): 1177–1183.

79. Jurasic MJ, Popovic IM, Morovic S, Trkanjec Z, Seric V, Demarin V. Can beta stiffness index be proposed as risk factor for dementia. J Neurol Sci 2009; 283(1–2): 13–16.

80. Modrego PJ, Rios C, Pérez Trullen JM, Errea JM, García-Gómara MJ, Sanchez S. The cerebrovascular pathology in Alzheimer’s disease and its influence on clinical variables. Am J Alzheimers Dis Other Demen 2008; 23(1): 91–96.

Štítky
Paediatric neurology Neurosurgery Neurology

Článok vyšiel v časopise

Czech and Slovak Neurology and Neurosurgery

Číslo 6

2012 Číslo 6
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