Validation of Myasthenia Gravis Quality of Life Questionnaire – Czech Version of MG-QOL15

Česká verzia

Authors: M. Horáková; S. Voháňka; J. Bednařík
Authors place of work: Neurologická klinika LF MU a FN Brno
Published in the journal: Cesk Slov Neurol N 2017; 80/113(1): 66-69
Category: Original Paper

Summary

Background:
In 2000, the Myasthenia Gravis Foundation of America task force recommended development of an MG-specific QOL measure. A 15-item Myasthenia Gravis Quality of Life 15 (MG-QOL15) scale was constructed in 2008. The questionnaire proved to be reliable and well correlated with other MG-scales (QMG, MG-ADL, MMT) and it quickly became a part of the evaluation of patients in clinical trials. The aim of our study was to establish an official Czech version, perform validation and enable the MG-QOL15 use in routine clinical practice.

Methods:
Czech translation was approved by a professional translator and then validated through forward-backward translation. Repeatability and reproducibility were tested on a sample of 40 patients. Patients completed the MG-QOL15 during a neuromuscular clinic visit and were asked to complete the second MG- QOL15 2–4 days later.

Results:
The Pearson correlation coefficient between the first and second completion was 0.993. For 95% of patients, the score did not differ by more than 2 points. Regression analysis of our data did not prove systematic bias with higher MG-QOL15 score. Cronbach alpha of 0.947 corresponds to high internal consistency of the questionnaire.

Conclusion:
The MG-QOL15 is an effective tool for monitoring the quality of life in patients with myasthenia. The official Czech translation allows the use of the questionnaire in routine clinical practice.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Key words:
myasthenia gravis – outcome measure – quality of life – validation – questionnaire

Chinese summary - 摘要

寿命验证问卷质量患者重症肌无力 - 在MG-QOL15捷克版本

摘要

简介：

2000年，工作队MGFA（美国重症肌无力基金会）推荐MG-QOL专用问卷的创建。 2008年它产生时包含15个问题并被命名为MG-QOL15的重症肌无力质量。问卷表明显著的可靠性，并与其他尺度非常好的相关性（QMG，MG-ADL，MMT）的患者在临床评价很快成为一部分研究。我们研究的目的是要建立一个正式的捷克语翻译执行其验证和主要是扩大MG-QOL15到临床实践中。

方法：

捷克语翻译被批准的专业翻译和验证方法反向翻译。重复性和再现性上的40样本测试

病人。第一份调查表，患者填写了例行检查时，并进行了一天2-4次的检查。

结果：

重复性分析用的皮尔逊系数为0.993。 95％患者有变异的两分中得分。回归分析，我们有我们的日期还没有随着总比分表现出更大的偏差。信度的值阿尔法0.947展示了调查问卷的内部一致性。

结论：

问卷的MG-QOL15是用于与监测生活质量的患者的有效工具重症。官方捷克语翻译允许在临床实践中运用问卷。

关键词：

重症肌无力 - 品种 - 生活质量 - 验证 - 专访

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