Hypothalamic inflammation and somatic diseases

Česká verzia

Authors: B. Mravec; A. S. Černáčková
Authors place of work: Biomedicínske centrum SAV, Ústav experimentálnej endokrinológie, Slovenská akadémia vied, Bratislava ; Fyziologický ústav, LF UK v Bratislave
Published in the journal: Cesk Slov Neurol N 2018; 81(3): 278-283
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2018278

Tato práca bola podporená grantom VEGA 2/ 0028/ 16 a grantom EÚ z programu cezhraničnej spolupráce Interreg V-A SK-AT V014 – NutriAging.

Summary

The hypothalamus represents a key structure involved in maintenance of homeostasis. Several factors, such as long-term increases in plasma levels of saturated fatty acids or pro-inflammatory cytokines, can induce hypothalamic inflammation. Hypothalamic inflammation disrupts homeostatic regulations and may contribute to the development of somatic diseases or may have a negative effect on the course of already existing somatic diseases. Hypothalamic inflammation plays a role in the etiopathogenesis of obesity, diabetes mellitus, hypertension, and cachexia. Understanding the causes and mechanisms involved in the development of hypothalamic inflammation allows for a more comprehensive view of the etiopathogenesis of somatic diseases and thus creates a basis for the introduction of new approaches in their treatment.

Keywords:
cytokines – diabetes mellitus – hypertension – hypothalamus – cachexia – obesity – ageing – stress – inflammation

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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