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Gam­ma knife stereotactic radiosurgery in recur­rent or residual glioblastoma multiforme – our experience in two neurosurgical units


Authors: R. Bartoš 1;  O. Šoula 2;  G. Šimonová 3;  A. Malucelli 1;  D. Šmejkalová-Musilová 4;  F. Třebický 5;  R. Liščák 3;  J. Klener 2;  M. Sameš 1
Authors place of work: Neurochirurgická klinika UJEP, Krajská zdravotní, a. s., Masarykova nemocnice v Ústí nad Labem, o. z. 1;  Neurochirurgické oddělení, Nemocnice Na Homolce, Praha 2;  Oddělení stereotaktické a radiační neurochirurgie, Nemocnice Na Homolce, Praha 3;  Onkologické oddělení, Krajská zdravotní a. s., Masarykova nemocnice v Ústí nad Labem o. z. 4;  Ústav radiační onkologie, Nemocnice Bulovka, Praha 5
Published in the journal: Cesk Slov Neurol N 2018; 81(5): 556-562
Category: Original Paper
doi: https://doi.org/10.14735/amcsnn2018556

Summary

This paper is a retrospective analysis of a 33 patient cohort with diagnosis of glioblastoma multiforme treated using gamma knife stereotactic radiation therapy following surgical resection and fractionated radiation therapy. Overall, 35 stereotactic radiation procedures were performed. Within this group, we differentiated patients who benefited from these procedures –  we managed to stabilise or achieve remission of the disease in 13 cases (37%) in a 3 month follow-up and in 6 cases (18%) in a 6-month follow-up. Long-term remission of this highly malignant tumor using gamma knife therapy was achieved in 4 patients.

Key words:
gamma knife – glioblastoma multiforme – radiotherapy

The author declares he has no potential con­flicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


Zdroje

1. Mahajan A, McCutcheon IE, Suki D et al. Case-control study of stereotactic radiosurgery for recur­rent glioblastoma multiforme. J Neurosurg 2005; 103(2): 210– 217. doi: 10.3171/ jns.2005.103.2.0210.

2. Shrieve DC, Alexander E 3rd, Wen PY et al. Comparison of stereotactic radiosurgery and brachyther­apy in the treatment of recur­rent glioblastoma multiforme. Neurosurgery 1995; 36(2): 275– 284.

3. Hsieh PC, Chandler JP, Bhangoo S et al. Adjuvant gam­ma knife stereotactic radiosurgery at the time of tumour progres­sion potential­ly improves survival for patients with glioblastoma multiforme. Neurosurgery 2005; 57(4): 684– 692.

4. Imber BS, Kanungo I, Braunstein S et al. Indications and ef­ficacy of gam­ma knife stereotactic radiosurgery for recur­rent glioblastoma: 2 decades of institutional experience. Neurosurgery 2017; 80(1): 129– 139. doi: 10.1227/ NEU.0000000000001344.

5. Frischer JM, Marosi Ch, Woehrer A et al. Gam­ma knife radiosurgery in recur­rent glioblastoma. Stereotact Funct Neurosurg 2016; 94(4): 265– 272. doi: 10.1159/ 000 448924.

6. Zwirner K, Paulsen F., Schittenhelm J et al. Prognostic parameters and outcome after re-ir­radiation for progres­sive glioblastoma. Acta Neurol Scand 2017; 136(3): 239– 245. doi: 10.1111/ ane.12719.

7. Nwokedi EC, DiBiase SJ, Jabbour S et al. Gam­ma knife stereotactic radiosurgery for patients with glioblastoma multiforme. Neurosurgery 2002; 50(1): 41– 47.

8. Souhami L, Seiferheld W, Brachman D et al. Randomized comparison of stereotactic radiosurgery fol­lowed by conventional radiother­apy with carmustine to conventional radiother­apy with carmustine for patients with glioblastoma multiforme: report of Radiation Ther­apy Oncology Group 93-05 protocol. Int J Radiat Oncol Biol Phys 2004; 60(3): 853– 860. doi: 10.1016/ j.ijrobp.2004.04.011.

9. Irish WD, MacDonald DR, Cairncross JG. Measur­­ing bias in uncontrol­led brain tumor trials– to randomize or not to randomize? Can J Neurol Sci 1997; 24(4): 307– 312.

10. Krex D, Klink B, Hartman C et al. Long-term survival with glioblastoma multiforme. Brain 2007; 130(10): 2596– 2606. doi: 10.1093/ brain/ awm204.

11. Duma CM, Kim BS, Chen PV et al. Upfront boost Gam­ma Knife „leading-edge“ radiosurgery to FLAIR MRI –  defined tumor migration pathways in 174 patients with glioblastoma multiforme: a 15-year as­ses­sment of a novel ther­apy. J Neurosurg 2016; 125 (Suppl 1): 40– 49. doi: 10.3171/ 2016.7.GKS161460.

Štítky
Paediatric neurology Neurosurgery Neurology

Článok vyšiel v časopise

Czech and Slovak Neurology and Neurosurgery

Číslo 5

2018 Číslo 5
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