Clonal hematopoiesis of indeterminate potential in ischemic stroke – study protocol

Česká verzia

Authors: M. Haršány ^1,2; V. Kunešová ¹; B. Kalousová ³; R. Slavkovský ³; J. Drábek ^3,4; J. Stránská- ^{3 5}; M. Hajdúch ³ ; R. Mikulík ^1,2
Authors place of work: Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně ¹; I. neurologická klinika LF MU a FN u sv. Anny v Brně ²; Ústav molekulární a translační medicíny, LF UP, Olomouc ³; Laboratoř experimentální medicíny, FN Olomouc ⁴; Neurologická klinika FN Olomouc ⁵
Published in the journal: Cesk Slov Neurol N 2022; 85(6): 496-500
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn2022496

Summary

Aim: The exact relationship between the gene mutation of hematopoietic cells (clonal hematopoiesis of indeterminate potential; CHIP) and the clinical manifestation has not yet been clearly described. The aim of this academic multicentric clinical study is to investigate the association between the presence of CHIP in peripheral blood and the incidence of ischemic stroke, and at the same time, to demonstrate whether CHIP contributes to the etiopathogenesis of atherosclerosis. This could lead to the identification of a new potential risk factor in the diagnosis of ischemic stroke predisposition. Methodology: This is a multicenter prospective study involving 14 primary and comprehensive stroke centers in the Czech Republic. The total number of enrolled patients aged ≥ 70 years is expected to be 1,000. The selected surgical centers will collaborate to provide 50 atherosclerotic plaque samples. Monitored parameters include personal and pharmacological history, laboratory parameters, neurological parameters, and results of selected imaging examinations. The expected outcome will be the definition of specific allelic variants and their frequencies as risk factors for the development of atherosclerosis and subsequent manifestation of ischemic stroke.

Keywords:

stroke – Mutation – Hematopoiesis – Atherosclerosis – ischemia – cell clones

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