Testing the effect of 2’, 3, 4’-trihydroxychalcone in experimental diabetes mellitus: a pilot study
Authors:
L. Bartošíková 1; J. Nečas 1; T. Bartošík 2; M. Pavlík 2
Authors place of work:
Univerzita Palackého Olomouc, Lékařská fakulta, Ústav fyziologie
1; Fakultní nemocnice U svaté Anny v Brně, Anesteziologicko-resuscitační klinika
2
Published in the journal:
Čes. slov. Farm., 2008; 57, 249-253
Category:
Original Articles
Summary
The effect of 2’, 3, 4’- trihydroxychalcone was monitored in the experimental conditions of alloxan-induced diabetes mellitus. The animals were divided by random selection into 2 groups (n = 7). The treated group was given chalcone in doses of 10 mg/kg in Avicel, the placebo group was given only a solution of Avicel. The last group was intact. Selected laboratory parameters (glucose, urea, cholesterol, antioxidative enzymes, total antioxidative capacity, malondialdehyde in serum; diuresis, total glucose and protein losses through urine) were determined. Kidney tissue and pancreas samples were taken for histopathological analysis. The results revealed a statistically significant decrease (p ≤ 0.01) in blood glucose level, a significant increase (p ≤ 0.01) in glutathione peroxidase, total antioxidative capacity (p ≤ 0.01) and a significant decrease (p ≤ 0.01) in the malondialdehyde level in the treated group compared to the placebo group. A highly significant decrease (p ≤ 0.01) in diuresis, glucose and protein losses through ureine was identified in the treated group compared to the placebo group. The superoxide dismutase catalytic activity, urea and cholesterol levels involved non-significant changes. The results of biochemical examination show a protective antioxidative and antihyperglycemic effect of tested chalcone. The results of histopathological examination correlate with them only partially.
Key words:
chalcones – diabetes mellitus – antioxidants
Zdroje
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Štítky
Pharmacy Clinical pharmacologyČlánok vyšiel v časopise
Czech and Slovak Pharmacy
2008 Číslo 6
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