Studies of local anaesthetics – Part 197
Effect of xylitol on pharmaceutical availability of lidocaine and flow properties of hydrogels

Česká verzia

Authors: Zuzana Vitková; Petra Herdová; Jozef Čižmárik; Daniel Grančai; Lukáš Benč
Authors place of work: Univerzita Komenského v Bratislave, Farmaceutická fakulta Katedra galenickej farmácie, Katedra farmaceutickej chémie, Katedra farmakognózie a botaniky
Published in the journal: Čes. slov. Farm., 2012; 61, 130-132
Category: Short News

Summary

The paper examines the formulation of hydrogel on the base of a synthetic polymer containing a local anaesthetic and a mass-produced drug in the form of a solution with an antiphlogistic effect. It aimed to prepare a hydrogel of a suitable composition with suitable flow properties and drug release, the active ingredient being lidocaine hydrochloride. Besides the role of a synthetic polymer which ensures that the active ingredient remains at the affected site, an important role in the formulation is played by the presence of an artificial sweetener, which to a great extent as a taste correcting agent of the unpleasant taste of the active ingredient influences the compliance of many patients. The study examined the effect of concentration of the artificial sweetener xylitol on the liberation of the active ingredient from prepared hydrogels. The optimum concentration of the artificial sweetener was adjusted to a degree which does not affect the qualitative properties of the active ingredient.

Keywords:
lidocaine hydrochloride, xylitol, hydrogel, liberation

Zdroje

1. Kołodziejska J.: Carbopol 974P in the prescription of dental anti-inflammatory hydrogels. Polim Med. 2008; 38, 27–38.

2. Čižmárik J., Matušová D., Vitková Z., Brázdovičová B., Herdová P.: Štúdium lokálnych anestetík. Časť: 192. Formulácia lidokaínu do gélov s protizápalovým účinkom. Čes. slov. Farm., 2010; 59, 277–279.

3. Duracher L., Blasco L., Hubaud J.C., Vian L., Marti-Mestres G.: The influence of alcohol, propylene glycol and 1,2-pentanediol on the permeability of hydrophilic model drug through excised pig skin. Int. J. Pharm. 2009; 374, 39–45.