The role of vitamin D in primary and secondary prevention in orthopaedic patients

1. Tsai K. S., Wahner H. W., Offord K. P., Melton L. J. 3rd, Kumar R., Riggs B. L. Effect of aging on vitamin D stores and bone density in women. Calcif. Tissue Int. 1987; 40(5), 241–243.

2. Webb A. R., Kline L., Holick M. F. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J. Clin. Endocrinol. Metab. 1988; 67(2), 373–378.

3. MacLaughlin J., Holick M. F. Aging decreases the capacity of human skin to produce vitamin D3. J. Clin. Invest. 1985; 76(4), 1536–1538.

4. Mithal A., Wahl D. A., Bonjour J. P., Burckhardt P., Dawson-Hughes B., Eisman J. A., El-Hajj Fuleihan G., Josse R. G., Lips P., Morales-Torres J., Group IOFCo- SANW. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int. 2009; 20, 1807–1820.

5. Bischoff-Ferrari H. A., Willett W. C., Wong J. B., Giovannucci E., Dietrich T., Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005; 293(18), 2257–2264.

6. Diamond T., Smerdely P., Kormas N., Sekel R., Vu T., Day P. Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism. Med. J. Aust. 1998; 169(3), 138–141.

7. Grant A. M., Avenell A., Campbell M. K., McDonald A. M., MacLennan G. S., McPherson G. C., Anderson F. H., Cooper C., Francis R. M., Donaldson C., Gillespie W. J., Robinson C. M., Torgerson D. J., Wallace W. A. & RECORD Trial Group. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005; 365(9471), 1621–1628.

8. Jackson R. D., LaCroix A. Z., Gass M., Wallace R. B., Robbins J., Lewis C. E., Bassford T., Beresford S. A., Black H. R., Blanchette P., Bonds D. E., Brunner R. L., Brzyski R. G., Caan B., Cauley J. A., Chlebowski R. T., Cummings S. R., Granek I., Hays J., Heiss G., … Women’s Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N. Engl. J. Med. 2006; 354(7), 669–683.

9. Rubinovitch M., Said S. E., Glorieux F. H.., Cruess R. L., Rogala E. Principles and results of corrective lower limb osteotomies for patients with vitamin D-resistant hypophosphatemic rickets. Clin. Orthop. Relat. Res. 1988; 237, 264–270.

10. Oh J. H., Kim S. H., Kim J. H., Shin Y. H., Yoon J. P., Oh C. H. The level of vitamin D in the serum correlates with fatty degeneration of the muscles of the rotator cuff. J. Bone Joint Surg. Br. 2009; 91(12), 1587–1593.

11. Jones G. Why dialysis patients need combination therapy with both cholecalciferol and a calcitriol analogs. Semin. Dial. 2010; 23(3), 239–243.

12. Robinson S. M., Reginster J. Y., Rizzoli R., Shaw S. C., Kanis J. A., Bautmans I., Bischoff-Ferrari H., Bruyère O., Cesari M., Dawson-Hughes B., Fielding R. A., Kaufman J. M., Landi F., Malafarina V., Rolland Y., van Loon L. J., Vellas B., Visser M., Cooper C. & ESCEO working group. Does nutrition play a role in the prevention and management of sarcopenia? Clinical nutrition 2018; 37(4), 1121–1132.

13. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Ross, A. C., Taylor, C. L., Yaktine, A. L.,& Del Valle, H. B. (Eds.). Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press (US) 2011.

14. Rosen C. J., Gallagher J. C. The 2011 IOM report on vitamin D and calcium requirements for north america: clinical implications for providers treating patients with low bone mineral density. J. Clin. Densitom. 2011; 14(2), 79–84.

15. Holick M. F., Binkley N. C., Bischoff-Ferrari H. A., Gordon C. M., Hanley D. A., Heaney R. P., Murad M. H., Weaver C. M., Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011; 96(7), 1911–1930.

16. Gehrig L. M., Collinge C., Kaufman J., Lane J. M., O’Connor M. I., Tosi L. L. Osteoporosis: management and densitometry for orthopaedic surgeons. Instr. Course Lect. 2009; 58, 805–815.

17. Holick M. F. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007; 24(12), 1017–1029.

18. Heaney R. P., Davies K. M., Chen T. C., Holick M. F., Barger- Lux M. J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol [published correction appears in Am J Clin Nutr. 2003; 78(5), 1047]. Am. J. Clin. Nutr. 2003; 77(1), 204–210.

19. Tangpricha V., Koutkia P., Rieke S. M., Chen T. C., Perez A. A., Holick M. F. Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am. J. Clin. Nutr. 2003; 77(6), 1478–1483.

20. Vieth R. Vitamin D toxicity, policy, and science. J. Bone Miner. Res. 2007; 22(Suppl 2), V64–V68.

21. Sanders K., Seibel M. New findings on vitamin D3 supplementation and falls — when more is perhaps not better. Nat. Rev. Endocrinol. 2016; 12, 190–191.

22. Sanders K. M., Stuart A. L., Williamson E. J., Simpson J. A., Kotowicz M. A., Young D., Nicholson G. C. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303(18), 1815–1822.

23. Gallagher J. C. Vitamin D and falls – the dosage conundrum. Nat. Rev. Endocrinol. 2016; 12(11), 680–684.

24. Beutler A. General principles of definitive fracture management. UpToDate 2019. General principles of definitive fracture management – UpToDate (cuni.cz).

25. Aniansson A., Hedberg M., Henning G. B., Grimby G. Muscle morphology, enzymatic activity, and muscle strength in elderly men: a follow-up study. Muscle Nerve 1986; 9(7), 585–591.

26. Hurley B. F. Age, gender, and muscular strength. J. Gerontol. A Biol. Sci. Med. Sci. 1995; 50(Spec No), 41–44.

27. Lexell J. Human aging, muscle mass, and fiber type composition. J. Gerontol. A Biol. Sci. Med. Sci. 1995; 50(Spec No), 11–16.

28. Plotnikoff G. A, Quigley J. M. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo. Clin. Proc. 2003; 78(12), 1463–1470.

29. Glerup H., Mikkelsen K., Poulsen L., Hass E., Overbeck S., Andersen H., Charles P., Eriksen E. F. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif. Tissue Int. 2000; 66(6), 419–424.

30. Bischoff-Ferrari H. A., Dietrich T., Orav E. J., Hu F. B., Zhang Y., Karlson E. W., Dawson-Hughes B. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am. J. Clin. Nutr. 2004; 80(3), 752–758.

31. Visser M., Deeg D. J., Lips P. Longitudinal Aging Study Amsterdam. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J. Clin. Endocrinol. Metab. 2003; 88(12), 5766–5772.

32. Wicherts I. S., van Schoor N. M., Boeke A. J., Visser M., Deeg D. J., Smit J., Knol D. L., Lips P. Vitamin D status predicts physical performance and its decline in older persons. J. Clin. Endocrinol. Metab. 2007; 92(6), 2058– 2065.

33. Buillon R. Vitamin D and extraskeletal health. UpToDate. 2012. https://www-uptodate-com.ezproxy.is.cuni.cz/ contents/vitamin-d-and-extraskeletal-health?search= - vitamin%20d%20muscle&source=search_result&selectedTitle= 1~150&usage_type=default&display_rank =1#H651640

34. Tinetti M. E., Inouye S. K., Gill T. M., Doucette J. T. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995; 273(17), 1348–1353.

35. Geusens P., Autier P., Boonen S., Vanhoof J., Declerck K., Raus J. The relationship among history of falls, osteoporosis, and fractures in postmenopausal women. Arch. Phys. Med. Rehabil. 2002; 83(7), 903–906.

36. Bischoff-Ferrari H. A., Dawson-Hughes B., Orav E. J., Staehelin H. B., Meyer O. W., Theiler R., Dick W., Willett W. C., Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern. Med. 2016; 176(2), 175–183.

37. Yao P., Bennett D., Mafham M., Lin X., Chen Z., Armitage J., Clarke R. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. JAMA Netw. Open. 2019; 2(12), e1917789.

38. World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study group Geneva: WHO, 1994 (Technical report Series 843). In: Osteoporosis prevention, diagnosis and therapy. JAMA 2001; 285, 785–795.

39. Kanis J. A., Johnell O., Aea O. Long-term risk of osteoporotic fracture in Malmö. Osteoporos. Int. 2000; 11(8), 669–674.

40. Nguyen N. D., Ahlborg H. G., Center J. R., Eisman J. A., Nguyen T. V. Residual lifetime risk of fractures in women and men. J. Bone Miner. Res. 2007; 22(6), 781–788.

41. Bliuc D., Nguyen N. D., Milch V. E., Nguyen T. V., Eisman J. A., Center J. R. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 2009; 301(5), 513–521.

42. Center J. R., Nguyen T. V., Schneider D., Sambrook P. N., Eisman J. A. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999; 353(9156), 878–882.

43. Langsetmo L., Goltzman D., Kovacs C. S., Adachi J. D., Hanley D. A., Kreiger N., Josse R., Papaioannou A., Olszynski W. P., Jamal S. A. & CaMos Research Group. Repeat low-trauma fractures occur frequently among men and women who have osteopenic BMD. J. Bone Miner. Res. 2009; 24(9), 1515–1522.

44. Doetsch A. M., Faber J., Lynnerup N., Wätjen I., Bliddal H., Danneskiold-Samsøe B. The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study. Calcif. Tissue Int. 2004; 75(3), 183–188.

45. Julia F. C. Treatment of Paget disease of bone. UpTo- Date 2020; https://www.uptodate.com/contents/treatment- of-paget-disease-of-bone?search=paget%20 disease%20vitamin%20d&source=search_result&selectedTitle= 2~150&usage_type=default&display_rank=2

46. Sprague S., Petrisor B., Scott T., Devji T., Phillips M., Spurr H., Bhandari M., Slobogean G. P. What Is the Role of Vitamin D Supplementation in Acute Fracture Patients? A Systematic Review and Meta-Analysis of the Prevalence of Hypovitaminosis D and Supplementation Efficacy. J. Orthop. Trauma. 2016; 30(2), 53–63.

47. Ettehad H., Mirbolook A., Mohammadi F., Mousavi M., Ebrahimi H., Shirangi A. Changes in the serum level of vitamin d during healing of tibial and femoral shaft fractures. Trauma Mon. 2014; 19(1), e10946.

48. Jones E. T. Skeletal growth and development as related to trauma. In: Green N. E., Swiontkowski M. F. (eds.) Skeletal Trauma in Children, 3rd ed. Philadelphia: Saunders 2003.

49. Gaston M. S, Simpson A. H. Inhibition of fracture healing. J. Bone Joint Surg. Br. 2007; 89, 1553.

50. Sprague S., Bzovsky S., Connelly D., Thabane L., Adachi J. D., Slobogean G. P. Study protocol: design and rationale for an exploratory phase II randomized controlled trial to determine optimal vitamin D3 supplementation strategies for acute fracture healing. Pilot Feasibility Stud. 2019; 5, 135.

51. deWeber K. Overview of stress fractures. UpToDate 2020. https://www-uptodate-com.ezproxy.is.cuni. cz/contents/overview-of-stres s-fractures?search= - stress%20fracture&source=search_result&selected- Title=1~140&usage_type=default&display_rank=1

52. Court-Brown C. M. Fractures of the tibia and fibula. In: Rockwood C. A., Bucholz R. W., Green D. P. (eds.) Rockwood and Green’s fractures in adults. Philadelphia: Lippincott Williams and Wilkins 2006; 2079–2046.

53. Ruohola J. P., Laaksi I., Ylikomi T., Haataja R., Mattila V. M., Sahi T., Tuohimaa P., Pihlajamäki H. Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men. J. Bone Miner. Res. 2006; 21(9), 1483–1488.

54. Wilkins K. E. Principles of fracture remodeling in children. Injury. 2005; 36(Suppl 1), A3–A11.

55. de Francisco A. L. Medical therapy of secondary hyperparathyroidism in chronic kidney disease: old and new drugs. Expert. Opin. Pharmacother. 2006; 7(16), 2215– 2224.

56. Lancourt J. E., Hochberg F. Delayed fracture healing in primary hyperparathyroidism. Clin. Orthop. Relat. Res. 1977; (124), 214–218.

57. Brinker M. R., O’Connor D .P., Monla Y. T., Earthman T. P. Metabolic and endocrine abnormalities in patients with nonunions. J. Orthop. Trauma 2007; 21(8), 557–570.

58. Mandl L. A. Determining who should be referred for total hip and knee replacements. Nat. Rev. Rheumatol. 2013; 9(6), 351–357.

59. Cherubino P., Ratti C., Fagetti A., Binda T. Total hip arthroplasty and bone fragility. Aging. Clin. Exp. Res. 2011; 23(2 Suppl), 76–77.

60. Spinarelli A., Petrera M., Vicenti G., Pesce V., Patella V. Total knee arthroplasty in elderly osteoporotic patients. Aging. Clin. Exp. Res. 2011; 23(2 Suppl), 78–80.

61. Mäkinen T. J., Alm J. J., Laine H., Svedström E., Aro H. T. The incidence of osteopenia and osteoporosis in women with hip osteoarthritis scheduled for cementless total joint replacement. Bone 2007; 40(4), 1041–1047.

62. Bischoff-Ferrari H. A., Orav E. J., Egli A., Dawson-Hughes B., Fischer K., Staehelin H. B., Rizzoli R., Hodler J., von Eckardstein A., Freystaetter G., Meyer U., Guggi T., Burckhardt P., Schietzel S., Chocano-Bedoya P., Theiler R., Willett W. C., Felson D. Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D. RMD Open 2018; 4(2), e000678.

63. Berry D. J. Epidemiology: hip and knee. Orthop. Clin. North. Am. 1999; 30(2), 183–190.

64. Della Rocca G. J., Leung K. S., Pape H. C. Periprosthetic fractures: epidemiology and future projections. J. Orthop. Trauma 2011; 25(Suppl 2), S66–S70.

65. Unnanuntana A., Dvorzhinskiy A., Rebolledo B.J., Doyle S. M., Andreopoulou P., Lane J. M. The role of vitamin D in Orthopedic Surgery. In: Feldman, D., Pike, J. W., Bouillon, R., Giovannucci, E., Goltzman, E., Hewison, M. eds. Vitamin D, 4th ed. London: Elsevier 2018.

66. Burkiewicz C. J., Guadagnin F. A., Skare T. L., do Nascimento M. M., Servin S. C., de Souza G. D. Vitamin D and skin repair: a prospective, double-blind and placebo controlled study in the healing of leg ulcers. Rev. Col. Bras. Cir. 2012; 39(5), 401–407.

67. MacKay D., Miller A. L. Nutritional support for wound healing. Altern. Med. Rev. 2003; 8(4), 359–377.

68. Colins N. Vitamin D is a hot topic. Does it have a role in wound healing? Adv. Skin Wound Care 2011; 24 (11), 498.

69. Dawson-Hughes B., Harris SS, Krall E. A., Dallal G. E. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N. Engl. J. Med. 1997; 337(10), 670–676.

70. Chapuy M. C., Pamphile R., Paris E., Kempf C., Schlichting M., Arnaud S., Garnero P., Meunier P. J. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos. Int. 2002; 13(3), 257–264.

71. Trivedi D. P., Doll R., Khaw K. T. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326(7387), 469.

72. Vieth R. What is the optimal vitamin D status for health? Prog. Biophys. Mol. Biol. 2006; 92(1), 26–32.

73. Dawson-Hughes B., Mithal A., Bonjour J. P., Boonen S., Burckhardt P., Fuleihan G. E., Josse R. G., Lips P., Morales-Torres J., Yoshimura N. IOF position statement: vitamin D recommendations for older adults. Osteoporos. Int. 2010; 21(7), 1151–1154.

74. American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for Prevention of Falls and Their Consequences. J. Am. Geriatr. Soc. 2014; 62(1), 147–152.

75. Hollis B. W. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J. Nutr. 2005; 135(2), 317–322.

76. Hollis B. W., Wagner C. L. Normal serum vitamin D levels. N. Engl. J. Med. 2005; 352(5), 515–516.

77. Zittermann A., Ernst J. B., Gummert J. F., Börgermann J. Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review. European journal of nutrition 2014; 53(2), 367–374.

78. Haines S. T., Park S. K. Vitamin D supplementation: what’s known, what to do, and what’s needed. Pharmacotherapy 2012; 32(4), 354–382.