Circadian Rhythms in Major Depressive Disorder
Authors:
L. Vavrušová
Authors place of work:
Psychiatrická klinika SZU, FNsP, Bratislava
Published in the journal:
Čes. a slov. Psychiat., 104, 2008, No. 5, pp. 241-245.
Category:
Comprehensive Reports
Summary
Treating the circadian alterations of mood disorders with chronobiotic agents is a new, promising therapeutic approach, and is a further step in the understanding of depression.
Agomelatine, the first melatonergic antidepressant, represents a novel pharmacological approach, and is a further step in understanding depression. Agomelatine is a new agent that enhances norepinephrine and dopamine neurotransmission by a unique mechanism, namely 5-HT2C antagonism with melatonin receptors 1 and 2 agonism.
Key words:
agomelatine, antidepressant, novel mechanism of action.
Zdroje
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Štítky
Addictology Paediatric psychiatry PsychiatryČlánok vyšiel v časopise
Czech and Slovak Psychiatry
2008 Číslo 5
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