The Association Study of the Relationship between Fourteen Candidate Gene Polymorphisms and Dispositions to the Alcoholism

Česká verzia

Authors: O. Šerý; J. Lochman; K. Gláslová ¹; R. Štaif; M. Novotný ¹; V. Kmoch ¹; P. Zvolský ¹
Authors place of work: Laboratoř neurobiologie a molekulární psychiatrie, Laboratoře molekulární fyziologie, Ústav biochemie, Přírodovědecká fakulta MU, Brno ředitel Ústavu biochemie doc. Ing. M. Mandl, CSc. Psychiatrická klinika 1. LF UK a VFN, Praha ; přednosta prof. MUDr. J. Raboch, DrSc. ¹
Published in the journal: Čes. a slov. Psychiat., 105, 2009, No. 4, pp. 153-162.
Category: Original Article

Summary

Predisposition to alcohol dependence is affected by multiple environmental and genetic factors. Modern molecular genetic techniques allow examining specific genes involved in the pathophysiology of complex diseases such as alcohol dependence. Between strategies for susceptibility gene identification are association studies. We carried out the association study of fourteen candidate gene polymorphisms and alcohol dependence. The association study was performed on 847 persons. We found the association between alcohol dependence and genes for COMT, MAO-B, IL6, IL2, LILRA1 and PSG11. All associated genes influence the neurodevelopment of central nervous system. We suppose the relationship between genes involved in the neurodevelopment of CNS and dispositions to the alcohol dependence.

Key words:
alcohol dependence, association study, polymorphism, gene, COMT, IL6, IL2, MAO, DAT1, DRD2.

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Štítky

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Článok vyšiel v časopise

Czech and Slovak Psychiatry

2009 Číslo 4

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