Chemotherapy during pregnancy

Česká verzia

Authors: Michael Jiří Halaška ¹ ; K. Šuchová ¹; I. Špálová ¹; H. Robová ¹ ; H. Stankušová ²; M. Pluta ¹; Lukáš Rob ¹
Authors place of work: Gynekologicko-porodnická klinika 2. LF UK a FN, Praha, přednosta prof. MUDr. L. Rob, CSc. ¹; Radioterapeuticko-onkologické oddělení FN Motol, Praha, primářka MUDr. J. Prausová, CSc. ²
Published in the journal: Ceska Gynekol 2009; 74(4): 252-256
Category: Original Article

Summary

Objective:
The aim of the study is to summarize current data on chemotherapy administered during pregnancy.

Type of study:
Review article.

Setting:
Dept. of Obstetrics and Gynaecology of the Charles University in Prague, 2nd Medical Faculty, University Hospital.

Subject and method:
Pubmed database was searched between the years 1980 and 2009 with the combinations of key words concerning cytostatics, therapy and pregnancy. Cisplatin administration was identified in 38 cases. Eight cases of administration of carboplatin during pregnancy were found with normal neonatal outcome Twenty-one case reports were found on the use of taxanes during pregnancy: 14 on paclitaxel and 7 on docetaxel.

Conclusion:
Based on the literature the administration of cytostatics during pregnancy can be considered under a close supervision and long term follow-up in dedicated teams.

Key words:
chemotherapy, pregnancy, therapy, paclitaxel, cisplatine, anthracycline.

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