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Preeclampsia – possibly prediction markers


Authors: J. Vokroj 1;  L. Arnoštová 2
Authors place of work: Gynekologicko-porodnická klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. A. Martan, DrSc. 1;  Ústav lékařské biochemie 1. LF UK Praha, přednosta prof. MUDr. S. Štípek, DrSc. 2
Published in the journal: Ceska Gynekol 2009; 74(4): 256-261
Category: Original Article

Summary

Objective:
The aim of our artical is give overwiew of prediction’s possibilities of preeclampsia. We give special attention to new markers.

Design:
Review article.

Settings:
Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic, Institute of Medical Biochemistry 1st Faculty of. Medicine, Charles University, Prague.

Methods:
Compilation of published data from scientific literature.

Conclusion:
Recent etiology’s hypothesis of preeclampsia are based on connection between well know pathophysiology and recent biochemistry mechanism. It ways to show new markers which could be used for earlier diagnostics in future. We need to find markers existing before clinical signs.

Key words:
preeclampsia, prediction, prediction markers, oxidative stress, angiogenesis.


Zdroje

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14. Rajasingam, D., Seed, PT., Briket, AL., et al. A prospective study of pregnancy outcome and biomarkers of oxidative stress in nulliparous obese women. Am J Obstet Gynecol, 2009, 5 (epub ahead of print).

15. Roberts, JM., Cooper, DW. Pathogenesis and genetics of pre-eclampsia. Lancet, 2001, 357, 9249, p. 53-56.

16. Soleymanlou, N., Jurisica, I., Nevo, O., et al. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab, 2005, 90, p. 4299-4308.

17. Spinnato, JA. 2nd., Freire, S., Pinto E., et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol, 2007, 110, 6, p. 1311-1318.

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Štítky
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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