Skin Reactions to New Agents (Biologicals and Targeted Anticancer Drugs)
Authors:
P. Cetkovská
Authors place of work:
Dermatovenerologická klinika FN a LFUK v Plzni
přednosta prof. MUDr. Karel Pizinger, CSc.
Published in the journal:
Čes-slov Derm, 85, 2010, No. 2, p. 68-75
Category:
Reviews (Continuing Medical Education)
Summary
In the last years, the knowledge of pathophysiology of immune diseases and cancer increased very rapidly. Better understanding of signal transduction and metabolic pathways enables to establish potential molecular targets of therapy. Targeted therapy brings better efficacy, safety profile and possibility of long-term treatment together with improved quality of life of seriously ill patients. On the other hand, it leads to unusual and unexpected side effects in comparison to immunosupressive or anti-cancer therapy. The article introduces the side effects of new targeted agents including biologicals and some new chemotherapeutic drugs.
Key words:
targeted anti-cancer therapy – biological therapy – chemotherapy – TNF α antagonists – EGFR inhibitors – multikinase inhibitors – inhibitors of proteasomes – monoclonal antibodies – skin side effects
Zdroje
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Štítky
Dermatology & STDs Paediatric dermatology & STDsČlánok vyšiel v časopise
Czech-Slovak Dermatology
2010 Číslo 2
Najčítanejšie v tomto čísle
- A Case Study of a Female with Atypical Localization of Syphilitic Chancre
- Skin Reactions to New Agents (Biologicals and Targeted Anticancer Drugs)
- Rosacea Fulminans
- Skin Side Effects of Epidermal Growth Factor Receptor Inhibitors in Oncologic Therapy