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The specific care about children born with assisted reproduction


Authors: D. Hrubá 1;  L. Greiffeneggová 1,2
Authors place of work: Ústav ochrany a podpory zdraví LF MU, Brno 1;  Katedra porodní asistence a zdravotnických záchranářů, LF MU, Brno 2
Published in the journal: Čes-slov Pediat 2017; 72 (6): 368-371.
Category: Review

Summary

The usage of the Assisted Reproductive Techniques (ART) is an exponentially growing trend worldwide and it is estimated, that especially in developed countries, 2–10% of newborns are currently being conceived in vitro. Epidemiologic and clinical studies have described the possible long-term deleterious effects on the health and welfare of both mothers threated with ART and their offsprings. We have evidence that conception via ART increasis the risk of serious pregnancy complications (especially preeclampsia, pre-term birth, low birth weight) and modification of the cardiovascular phenotype towards higher risk of arterial hypertension, cardiovascular diseases, diabetes mellitus and pulmonary hypertension in childhood and adulthood. Both ART and preeclampsia are considered to be new inclusions in the list of cardiovascular risk factors. Even if the absolute risk seems small, it is necessary to formulate a plan of the specific care, from periconception to the puerperium and follow-up years after delivery for obstetricians and primary care physicians to minimise maternal and infant morbidity and preterm mortality.

KEY WORDS:
assisted reproduction, pregnancy complications, cardiovascular risk


Zdroje

1. Talaulikar VS, Arulkumaran S. Maternal perinatal and long-term outcomes after assisted reproductive techniques (ART): implications for clinical practice. Eur J Obstet Gynecol Reprod Biol 2013; http://dx.doi.org/10.1016/j.ejogrb.2013.04.014.

2. Kamphuis EI, Bhazzacharya D, van der Veen F, et al. Are we over-using IVF? BMJ 2014; 348g252.

2. Crha I. Vybrané kapitoly z reprodukční medicíny. Brno: Masarykova univerzita, 2010.

3. Van der Lende T, de Loos FAM, Jorna TJ. Postnatal health and welfare of offsprings conceived in vitro: a case for epidemiological studies. Theriogenology 2000; 53: 549–554.

4. Žáková J, Ventruba P, Crha I, a spol. Nové metody zvyšující úspěšnost asistované reprodukce. Čes Gynek 2012; 44 (2): 139–142.

5. Child TJ, Phillips SJ, Abdul-Jalil AK, et al. A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries. Obstet Gynecol 2002; 100: 665–670.

6. Hansen AT, Kesmodel US, Juul S, et al. Increased venous thrombosis incidence in pregrancies after in vitro fertilization. Hum Reprod 2014; 29: 611–617.

7. Goncalves PB, Ferreira R, Gasperin B, et al. Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent Advances. Reproduction 2012; 143: 11–20.

8. Henriksson P, Westerlund E, Wallén H, et al. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization: cross sectional study. BMJ 2013; 346: e8632.

9. Udell JA, Lu H, Redelmeier DA. Faulure of fertility therapy and subsequent adverse cardiovascular events. CMAJ 2017; 189: E391–397.

10. Filipčíková R, Březinová J, Oborná I, a spol. Výskyt vybraných geneticky podmíněných trombofilních markerů u pacientek postupujících léčbu neplodnosti. Čes Gynek 2013; 78 (1): 73–77.

11. Hrubá D. Vliv kouření cigaret na klinické výsledky asistované reprodukce: meta-analýza. Prakt Gyn 2009; 13 (1): 1–2.

12. Svitáková M, Čadová K, Crha I, a spol. Vliv výživy na výsledky léčby neplodnosti metodami IVF/ET. Prakt Gyn 2010; 14: 85–88.

13. Crha I, Hrubá D, Ventruba P, et al. Ascorbic acid and infertility treatment. Cent Eur J Publ Health 2003; 11 (2): 11–15.

14. McDonald SD, Han Z, Mulla S, et al. Preterms birth and low birth weight among in vitro fertilization twins: a systematic review and meta – analysis. Eur J Obstet Gynecol Reprod Biol 2010; 148: 105–113.

15. In vitro fertilization: perinatal risks and early childhood outcomes: scientific impact paper 8. UK. Royal College of Obstetricians and Gynaecologists, RCOG, 2012. In: Talaulikar VS, Arulkumaran S. Maternal perinatal and long-term outcomes after assisted reproductive techniques (ART): implications for clinical practice. Eur J Obstet Gynecol Reprod Biol 2013; http://dx.doi.org/10.1016/j.ejogrb.2013.04.014.

16. Davies MJ, Moore VM, Wilson KJ, et al. Reproductive technologies and the risk of birth defects. N Engl J Med 2012; 366: 1803–1813.

17. Basatermur E, Suteliffe A. Health of IVM children. J Assist Reprod Genet 2011; 28: 489–493.

18. Kallen B, Finnstrom O, Lindam A, et al. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics 2010; 126: 270–276.

19. Barker DJ. The fetal and infant origins of disease. Eur J Clin Invest 1995; 25: 457–463.

20. Kajantie E, Eriksson JG, Osmond C, et al. Pre-eclampsia is associated with increased risk od stroke in the adult offsprings: the Helsinki birth cohort study. Stroke 2009; 40: 1176–1180.

21. Jayet PY. Rimoldi SF, Stuber T, et al. Pulmonary and systemic vascular dysfunction in young offsprings of mothers with preeclampsia. Circulation 2010; 0122: 488–494.

22. Valenzuela-Alcaraz B, Crispi F, Bijnens B, et al. Assisted reproductive technologies are associated with cardiovascular remodelling in utero that persist postnatally. Circulation 2013; 0128: 1442–1450.

23. Chen X, Wang Y. Tracking blood pressure from childhood to adulthood: a systematic review and meta-analysis. Circulation 2008; 117: 3171–3180.

24. Scherrer U, Rexhaj E, Allemann Y, et al. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur Heart J 2015 April 23; doi:10.1093/eurheartj/ehv145.

25. Duplan H, Burcelin R, Sartori C, et al. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 2001; 104: 342–345.

26. Whitelaw NC, Whitelaw E. Transgenerational epigenetic inherence in Health and disease. Curr Opin Genet Dev 2008; 018: 273–279.

27. Rondo PH, Lemos JO, Pereira JA, Souza JM. The relationship between cortisol concentrations in pregnancy and systemic vascular resistance in childhood. Early Hum Dev 10; 086: 547–553.

28. Hudeček R. Ovariální hyperstimulační syndrom v programu asistované reprodukce: analýza rizikových faktorů. Disertační práce 2006, Brno; dostupné na: www/os.muni.cz/rh77349/if_d.

29. Ventruba P, Žáková J, Trávník P, a spol. Aktuální otázky asistované reprodukce v České republice. Čes Gynekol 2013; 78 (4): 378–384.

Štítky
Neonatology Paediatrics General practitioner for children and adolescents
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