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PAG: A POTENTIAL TUMOUR SUPPRESSOR AND HOW IT ALL STARTED. FROM IMMUNE SIGNALLING TO NEOPLASTIC TRANSFORMATION


Authors: A. Švec
Authors place of work: Department of Cellular Pathology, James Cook University Hospital, Middlesbrough, United Kingdom
Published in the journal: Čes.-slov. Patol., 45, 2009, No. 2, p. 35-39
Category: Reviews Article

Summary

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG) also known as Csk-binding protein was first fully

characterized in 2000. It was initially recognized as a ubiquitously expressed adaptor protein recruiting cytoplasmic C-terminal Src-kinase

to the close proximity of plasma membrane-anchored Src-kinases thereby allowing Csk to impose its inhibitory potential on these kinases.

A role of PAG was initially seen in negative regulation of immune reactions. Since the year 2000 other Csk-dependent and independent

interactions have been discovered and some of them showed anti-oncogenic effects in experiment. According to current opinions, these

findings place PAG in a position of tumour suppressor candidate.

Key words:

PAG – Cbp – immune signalling – oncogenesis


Zdroje

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Štítky
Anatomical pathology Forensic medical examiner Toxicology
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