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Thyroid Carcinoma in Children and Adolescents Resulting from the Chernobyl Accident: Possible Causes of the Incidence Increase Overestimation


Authors: S. V. Jargin
Authors place of work: Peoples’ Friendship University of Russia (Moscow)
Published in the journal: Čes.-slov. Patol., 45, 2009, No. 2, p. 50-52
Category: Original Article

Summary

The Chernobyl accident in the nuclear power plant on 26th April 1986 was followed by numerous publications overestimating the medical consequences of the disaster. In the publications, interpretations of spontaneous diseases as radiation-induced, indication of radioactivity or dose levels without confrontation with the natural radiation background, or conclusions about incidence increase without comparison with the increase tendencies in larger regions or the whole country, can be found. Improved diagnostics after the Chernobyl accident is not always taken into account. The high figures could have been caused in some cases by non-random material selection or inadequate morphological assessment of biopsy specimens. The application of the linear-no-threshold theory to the inhabitants of contaminated areas contributed to an overestimation of medical consequences of the Chernobyl accident as well. The incidence increase of thyroid carcinoma in children and adolescents started in 1990, four years after the accident. High tumor expectancy after the accident, in the circumstances of limited technical possibilities and outdated equipment of histological laboratories, contributed to a higher number of registered cases. The quality of specimens necessary for the assessment of nuclear criteria of papillary carcinoma was not always achieved at that time. The incidence increase of thyroid carcinoma can, at least in part, be explained by improved detection of thyroid nodules with occasional false-positive conclusions about malignancy. Besides, latent carcinomas and well-differentiated thyroid tumors of uncertain malignant potential, diagnosed as malignancies, could have additionally contributed to the high figures.

Key words:
thyroid carcinoma – pediatric cancer – Chernobyl accident – radiation pathology


Zdroje

1. Abrosimov A.Iu.: Thyroid carcinoma in children and adolescents of Russian Federation after the Chernobyl accident, Doctoral dissertation (in Russian), Obninsk, 2004.

2. Abrosimov A.Iu., Lushnikov E.F., Frank G.A.: Radiogenic (Chernobyl) thyroid cancer (in Russian with English summary). Arkh. Patol., 63(4), 2001, s. 3–9.

3. Balonov M.: Third annual Warren K. Sinclair keynote address: retrospective analysis of impacts of the Chernobyl accident. Health Phys., 93, 2007, s. 383–409.

4. Bogdanova T.I., Kozyritskij V.G., Tronko N.D.: Thyroid pathology in children, Atlas (in Russian), Kiev, Chernobylinterinform, 2000.

5. Bogdanova T., Zurnadzhy L., Tronko M. et al.: Pathology of thyroid cancer in children and adolescents in Ukraine having been exposed as a result of the Chernobyl accident. International Congress Series, 1299, 2007, s. 256–262.

6. Bomash N.Iu.: Morphological diagnostics of thyroid diseases (in Russian), Moscow, Meditsina, 1981.

7. Cardis E.: Current status and epidemiological research needs for achieving a better understanding of the consequences of the Chernobyl accident. Health Phys., 93, 2007, s. 542-546.

8. Chernobyl’s Legacy: Health, Environmental and Socio-Economic Impacts and Recommendations to the Governments of Belarus, the Russian Federation and Ukraine, IAEA, Vienna, 2006.

9. Chow L.S., Gharib H., Goellner J.R., van Heerden J.A.: Nondiagnostic thyroid fine-needle aspiration cytology: management dilemmas. Thyroid., 11, 2001, s. 1147–1151.

10. Demidchik YE, Saenko VA, Yamashita S.: Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present. Arq. Bras. Endocrinol. Metabol., 51, 2007, s. 748–762.

11. Demidchik E.P., Tsyb A.F., Lushnikov E.F.: Thyroid carcinoma in children. Consequences of Chernobyl accident (in Russian), Moscow, Meditsina, 1996.

12. Fonseca E., Soares P., Cardoso-Oliveira M., Sobrinho-Simões M.: Diagnostic criteria in well-differentiated thyroid carcinomas. Endocr. Pathol., 17, 2006, s. 109–117.

13. Holm L.E.: Thyroid cancer after exposure to radioactive 131I. Acta Oncol., 45, 2006; s. 1037–1040.

14. Jargin S.V.: On the overestimation of Chernobyl NPP accident consequences. Med. Radiol. and Radiation Safety (in Russian), 52 (1), 2007, s. 73–74.

15. Jargin S.V.: On the overestimation of Chernobyl NPP accident effects: urinary bladder tumors. Med. Radiol. and Radiation Safety (in Russian), 52 (4), 2007, s. 83–84.

16. Jargin S.V.: Over-estimation of radiation-induced malignancy after the Chernobyl accident. Virchows Arch., 451, 2007, s. 105–106.

17. Jargin S.V.: Re: Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans and Re: DNA damage repair in bladder urothelium after the Chernobyl accident in Ukraine. J. Urol., 177, 2007, s. 794–799.

18. Khurana K.K., Baloch Z.W., LiVolsi V.A.: Aspiration cytology of pediatric solitary papillary hyperplastic thyroid nodule. Arch. Pathol. Lab. Med., 125, 2001, s. 1575–1578.

19. Kraievski N.A., Smolyannikov A.V., Sarkisov D.S. (Editors): Patho-morphological diagnostics of human tumors. Handbook for physicians (in Russian), Moscow, Meditsina, 1993.

20. Mai K.T., Landry D.C., Thomas J. et al.: Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. Histopathology, 39, 2001, s. 25–32.

21. Nikiforov Y., Gnepp D.R.: Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991–1992) from the Republic of Belarus. Cancer, 74, 1994, s. 748–766.

22. Omutov M., Jargin S.V.: The practice of pathology in Russia. Abstracts of the 21st European Congress of Pathology. Virchows Arch. 451, 2007, s. 277.

23. Paltsev M.A., Anichkov N.M.: Atlas of human tumor pathology (in Russian), Moscow, Meditsina, 2005.

24. Parshikov E.M., Sokolov V.A., Proshin A.D., Kurnosova L.V.: Characteristics of thyroid cancer incidence in children residing in radio-contaminated areas (in Russian). In: Chernobyl legacy. Proceedings of the scientific and practical conference. Vol. 4, Kaluga, 2006, s. 132–134.

25. Reiners C, Demidchik YE, Drozd VM, Biko J.: Thyroid cancer in infants and adolescents after Chernobyl. Minerva Endocrinol., 33, 2008, s. 381–395.

26. Rosai J.: Rosai and Ackerman’s Surgical Pathology. Vol. 1, Edinburgh: Mosby, 2004, s. 515-594.

27. Tronko M.D., Bogdanova T.I., Komissarenko I.V. et al.: Thyroid carcinoma in children and adolescents in Ukraine after the Chernobyl nuclear accident: statistical data and clinicomorphologic characteristics. Cancer, 86, 1999, s. 149–156.

28. Tsyb A.F., Ivanov V.K., Matvienko E.G.: Medical radiological consequences of Chernobyl accident for the population of Russia. In: Chernobyl legacy. Proceedings of the scientific and practical conference. Vol. 4, Kaluga, 2006, s. 13–21.

29. UNITED NATIONS. Sources and effects of ionizing radiation. UNSCEAR 2000 Report to the General Assembly, Vol. 1. Sources and effects of ionizing radiation, United Nations, New York, 2000, s. 15.

30. Williams ED.: Chernobyl and thyroid cancer. J. Surg. Oncol., 94, 2006, s. 670–677.

Štítky
Anatomical pathology Forensic medical examiner Toxicology
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