Phylogenetic Analysis and Genotyping of A/H3N2 Influenza Viruses Isolated from Patients Hospitalised with Influenza-Like Illness Symptoms in the Na Bulovce Hospital in the Season 2011/2012
Authors:
Nagy Alexander 1; Jiřincová Helena 1; Havlíčková Martina 1; Džupová Olga 2,4; Herrmannová Kristýna 3,4; Trojánek Milan 3,4; Marešová Vilma 3,4; Nováková Ludmila 1; Kynčl Jan 1
Authors place of work:
Státní zdravotní ústav, Centrum epidemiologie a mikrobiologie, Praha
1; 3. lékařská fakulta, Univerzita Karlova v Praze
2; 2. lékařská fakulta, Univerzita Karlova v Praze
3; Klinika infekčních nemocí, Nemocnice Na Bulovce, Praha
4
Published in the journal:
Epidemiol. Mikrobiol. Imunol. 62, 2013, č. 1, s. 4-8
Summary
Influenza A virus is an important cause of acute respiratory infections (ARI). Clinical manifestations of ARI vary from mild or moderate to life-threatening conditions requiring intensive care. Given the segmented genome, a large natural reservoir of other influenza virus subtypes, and antibody selection pressure in the population, the virus is variable and genetically unstable. The phylogenetic analysis and genotyping of A/H3N2 influenza viruses isolated from patients hospitalised with influenza-like illness symptoms in the Na Bulovce Hospital in the season 2011/2012 support the assumption that the pathogenicity is a polygenic trait modifiable by the host health status and seems not to be unambiguously associated with any specific mutations.
Keywords:
influenza A virus, phylogenetic analysis – genotyping – hospitalization – clinical symptoms
Zdroje
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Štítky
Hygiene and epidemiology Medical virology Clinical microbiologyČlánok vyšiel v časopise
Epidemiology, Microbiology, Immunology
2013 Číslo 1
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