Tick-borne encephalitis – pathogenesis and therapeutic approaches
Authors:
D. Růžek 1,2
Authors place of work:
Oddělení virologie, Výzkumný ústav veterinárního lékařství, Brno
1; Laboratoř arbovirologie, Parazitologický ústav Biologického centra Akademie věd České republiky, České Budějovice
2
Published in the journal:
Epidemiol. Mikrobiol. Imunol. 64, 2015, č. 4, s. 204-209
Category:
Review Article
Summary
Tick-borne encephalitis (TBE) is a major public health threat in large areas of Central and Eastern Europe and in Russia. This review summarizes the current data on the interactions between the TBE virus and the host, with a particular focus on the mechanisms of neuronal injury, immune response and immunopathology in the central nervous system (CNS), and factors that determine the course and outcome of TBE. Novel trends of experimental therapy of TBE are discussed. Combining small molecule inhibitors targeting viral replication with immunomodulatury agents might be a way to maximize viral clearance and minimize immunopathology in the CNS during TBE.
Keywords:
tick-borne encephalitis virus – tick-borne encephalitis – antiviral therapy – pathogenesis
Zdroje
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Štítky
Hygiene and epidemiology Medical virology Clinical microbiologyČlánok vyšiel v časopise
Epidemiology, Microbiology, Immunology
2015 Číslo 4
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