Rivaroxaban in patients with diabetes mellitus and atrial fibrillation

Česká verzia

Authors: Monika Péčová ^1,2; Jakub Benko ³; Martin Jozef Péč ³; Tomáš Bolek ³; Juraj Sokol ¹; Matej Samoš ³; Eva Hajtmanová ²; Ján Staško ¹; Marián Mokáň ³
Authors place of work: Klinika hematológie a transfuziológie JLF UK a UNM, Martin ¹; Onkologické centrum UNM, Martin ²; I. interná klinika JLF UK a UNM, Martin ³
Published in the journal: Forum Diab 2022; 11(2): 87-93
Category:

Summary

The prevalence of atrial fibrillation and diabetes mellitus is rising, and these disorders frequently occur simultaneously. Diabetes mellitus is an independent risk factor of ischemic stroke and systemic embolism in patients with atrial fibrillation. Moreover, patients with atrial fibrillation-associated stroke and concomitant diabetes mellitus seem to have worse outcome compared to non-diabetic patients. Intensive activation of coagulation, decreased fibrinolytic activity, changes in platelet and endothelial function, together with increased levels of tissue plasminogen activator and factor VIII activity might directly link diabetes mellitus with atrial fibrillation-associated stroke. Long-term anticoagulation is indicated in majority of patients with diabetes mellitus and atrial fibrillation to prevent adverse embolic events connected with atrial fibrillation. This article reviews up-to-date literature regarding the use of rivaroxaban in patients with diabetes mellitus and with atrial fibrillation.

Keywords:

atrial fibrillation – diabetes mellitus – rivaroxaban – direct oral anticoagulants

Zdroje

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