Serum concentration of S100P protein in patients with colorectal cancer

Česká verzia

Authors: Petra Morávková ¹ ; D. Kohoutová ¹; M. Drahošová ²; J. Bureš ¹
Authors place of work: II. interní gastroenterologická klinika LF UK a FN Hradec Králové ¹; Ústav klinické imunologie a alergologie, LF UK a FN Hradec Králové ²
Published in the journal: Gastroent Hepatol 2017; 71(4): 293-298
Category: Clinical and Experimental Gastroenterology: Original Article
doi: https://doi.org/10.14735/amgh2017293

Summary

Background:
Colorectal cancer (CRC) is the third most frequent cancer worldwide and in the Czech Republic. S100P protein plays a significant role in colorectal carcinogenesis and in tumour metastatic progression. The aim of this prospective study was to assess the association between serum concentration of S100P protein and CRC.

Methods:
The study included 79 subjects – 36 controls and 43 patients with CRC. The CRC group was divided into subgroups according to tumour side (13 patients with right-sided CRC (CRC-R group) and 30 patients with left-sided CRC (CRC-L group)); stage of the disease (9 patients in clinical stage I, 7 in stage II, 13 in stage III and 13 in stage IV); and tumour grading (5 patients with well-differentiated tumour (G1), 24 patients with moderately-differentiated tumour (G2) and 11 patients with poorly-differentiated tumour (G3)). Serum concentrations of S100P protein were measured in peripheral blood samples using ELISA.

Results:
Serum S100P was significantly higher in the CRC group (median: 1251; inter-quartile range (IQR): 731–1749 ng/L) than in the controls (median: 765; IQR: 545–1158 ng/L); p = 0.012. Compared to the control group, serum S100P was significantly higher in patients with left-sided tumours (median: 1426; IQR: 739–1925 ng/L; p = 0.005), in clinical stage IV (median: 1622; IQR: 778–2154 ng/L; p = 0.008) and in patients with moderately-differentiated tumours (median: 1318; IQR: 853–1879 ng/L; p = 0.005). No difference was observed in the CRC-R group when compared with the controls and CRC-L group; p > 0.05.

Conclusion:
The study confirms a relationship between serum concentration of S100P protein and CRC. Significantly higher serum levels were observed in patients in clinical stage IV and patients with left-sided carcinoma.

Key words:
S100P – biomarker – colorectal cancer

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
7. 6. 2017

Accepted:
31. 7. 2017

Zdroje

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