Inflammatory bowel disease and male fertility
Authors:
Novák J. 1,2; Vik V. 2,3; Malíčková K. 2,4; Krátká Z. 2
Published in the journal:
Gastroent Hepatol 2019; 73(2): 132-137
Category:
IBD: Review Article
doi:
https://doi.org/10.14735/amgh2019132
Summary
Up to 15% of couples are diagnosed with infertility. The male cause of infertility is being found in up to 50% of couples. There is a correlation between sperm quality and male health status. Sperm quality is frequently decreased in inflammatory bowel disease patients, especially those in the active disease phase. This decrease is due to both the disease and its treatment. This article summarises knowledge of male infertility in inflammatory bowel disease patients from urological and immunological view points, and should be useful for gastroenterologists and patients who are considering trying to conceive.
Conflict of Interest: Authors declare that the article/manuscript complies with ethical standards, patient anonymity has been respected, and states that they have no financial, advisory or other commercial interests in relation to the subject matter.
Publication Ethics: The article/manuscript has not been published or is currently being submitted to another review. The authors agree to publish their name and e-mail in the published article/manuscript.
Dedication: Supported by Ministry of Health, Czech Republic – conceptual development of research organization 64165, General University Hospital in Prague, Czech Republic.
The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.
Submitted: 11. 1. 2019
Accepted: 19. 2. 2019
Keywords:
infertility – sulfasalazine – azathioprine – infliximab
Zdroje
1. Palomba S, Sereni G, Falbo A et al. Inflammatory bowel diseases and human reproduction: a comprehensive evidence-based review. World J Gastroenterol 2014; 20 (23): 7123–7136. doi: 10.3748/wjg.v20.i23.7123.
2. van der Woude CJ, Ardizzone S, Bengtson MB et al. The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohns Colitis 2015; 9 (2): 107–124. doi: 10.1093/ecco-jcc/jju006.
3. Semet M, Paci M, Saïas-Magnan J et al. The impact of drugs on male fertility: a review. Andrology 2017; 5 (4): 640–663. doi: 10.1111/andr.12366.
4. Mountifield R, Bampton P, Prosser R et al. Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions. Inflamm Bowel Dis 2009; 15 (5): 720–725. doi: 10.1002/ibd.20839.
5. Tavernier N, Fumery M, Peyrin-Biroulet L et al. Systematic review: fertility in non-surgically treated inflammatory bowel disease. Aliment Pharmacol Ther 2013; 38 (8): 847–853. doi: 10.1111/apt.12478.
6. Agarwal A, Mulgund A, Hamada A et al. A unique view on male infertility around the globe. Reprod Biol Endocrinol 2015; 13: 37. doi: 10.1186/s12958-015-0032-1.
7. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol 2012; 62 (2): 324–332. doi: 10.1016/j.eururo.2012.04.048.
8. Sharlip ID, Jarow JP, Belker AM et al. Best practice policies for male infertility. Fertil Steril 2002; 77 (5): 873–882.
9. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. [online]. Available from: https: //apps.who.int/iris/bitstream/handle/10665/44261/9789241547789_eng.pdf; jsessionid=F8BAC2793E1EA2A96C1D7A14E67D93DB?sequence=1.
10. Krátká Z, Luxová Š, Vik V. Využití průtokové cytometrie pro stanovení kvality ejakulátu u mužů s poruchou reprodukce. Ces Urol 2017; 21 (4): 289–298.
11. Dimitrova D, Kalaydjiev S, Mendizova A et al. Circulating antibodies to human spermatozoa in patients with ulcerative colitis. Fertil Steril 2005; 84 (5): 1533–1535. doi: 10.1016/j.fertnstert.2005.05.041.
12. O’Moráin C, Smethurst P, Doré CJ et al. Reversible male infertility due to sulphasalazine: studies in man and rat. Gut 1984; 25 (10): 1078–1084. doi: 10.1136/gut.25.10. 1078.
13. Mogilner J, Elenberg Y, Lurie M et al. Effect of dexamethasone on germ cell apoptosis in the contralateral testis after testicular ischemia−reperfusion injury in the rat. Fertil Steril 2006; 85 (Suppl 1): 1111–1117. doi: 10.1016/j.fertnstert.2005.10.021.
14. Valer P, Algaba A, Santos D et al. Evaluation of the quality of semen and sexual function in men with inflammatory bowel disease. Inflamm Bowel Dis 2017; 23 (7): 1144–1153. doi: 10.1097/MIB.0000000000001081.
15. Puchner R, Danninger K, Puchner A et al. Impact of TNF-blocking agents on male sperm characteristics and pregnancy outcomes in fathers exposed to TNF-blocking agents at time of conception. Clin Exp Rheumatol 2012; 30 (5): 765–767.
16. Mahadevan U, Terdiman JP, Aron J et al. Infliximab and semen quality in men with inflammatory bowel disease. Inflamm Bowel Dis 2005; 11 (4): 395–399.
17. Saougou I, Markatseli TE, Papagoras C et al. Fertility in male patients with seronegative spondyloarthropathies treated with infliximab. Joint Bone Spine 2013; 80 (1): 34–37. doi: 10.1016/j.jbspin.2012.03.004.
18. Micu MC, Micu R, Surd S et al. TNF-α inhibitors do not impair sperm quality in males with ankylosing spondylitis after short-term or long-term treatment. Rheumatology 2014; 53 (7): 1250–1255. doi: 10.1093/rheumatology/keu007.
19. Villiger PM, Caliezi G, Cottin V et al. Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis. Ann Rheum Dis 2010; 69 (10): 1842–1844. doi: 10.1136/ard. 2009.127423.
20. Ramonda R, Foresta C, Ortolan A et al. Influence of tumor necrosis factor α inhibitors on testicular function and semen in spondyloarthritis patients. Fertil Steril 2014; 101 (2): 359–365. doi: 10.1016/j.fertnstert.2013.10.048.
21. Grosen A, Bungum M, Christensen LA et al. Semen quality and sperm DNA Integrity in patients with severe active inflammatory bowel disease and effects of tumour necrosis factor-alpha inhibitors. J Crohns Colitis 2018. doi: 10.1093/ecco-jcc/jjy198.
22. Said TM, Agarwal A, Falcone T et al. Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model. Fertil Steril 2005; 83 (6): 1665–1673. doi: 10.1016/j.fertnstert.2004.11.068.
23. Dejaco C, Mittermaier C, Reinisch W et al. Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology 2001; 121 (5): 1048–1053.
24. Leroy C, Rigot JM, Leroy M et al. Immunosuppressive drugs and fertility. Orphanet J Rare Dis 2015; 10: 136. doi: 10.1186/ s13023-015-0332-8.
25. Palomba S, Sereni G, Falbo A et al. Inflammatory bowel diseases and human reproduction: a comprehensive evidence-based review. World J Gastroenterol 2014; 20 (23): 7123–7136. doi: 10.3748/wjg.v20.i23.7123.
26. Masuda H, Fujihira S, Ueno H et al. Ultrastructural study on cytotoxic effects of cyclosporine A in spermiogenesis in rats. Med Electron Microsc 2003; 36 (3): 183–191. doi: 10.1007/s00795-003-0213-4.
27. Türk G, Ateşşahin A, Sönmez M et al. Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology 2007; 67 (4): 778–785. doi: 10.1016/j.theriogenology.2006.10.013.
28. Bouloux PM, Wass JA, Parslow JM et al. Effect of cyclosporin A in male autoimmune infertility. Fertil Steril 1986; 46 (1): 81–85.
29. Sakamoto Y, Matsumoto T, Kumazawa J. Cell-mediated autoimmune response to testis induced by bilateral testicular injury can be suppressed by cyclosporin A. J Urol 1998; 159 (5): 1735–1740. doi: 0.1097/00005392-199805000-00103.
30. Latif T, Kold Jensen T, Mehlsen J et al. Semen quality as a predictor of subsequent morbidity: a danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol 2017; 186 (8): 910–917. doi: 10.1093/aje/kwx067.
31. Omu AE. Sperm parameters: paradigmatic index of good health and longevity. Med Princ Pract 2013; 22 (Suppl 1): 30–42. doi: 10.1159/000354208.
32. Kobayashi H, Tamura K, Tai T et al. Semen cryopreservation as an oncofertility treatment in 122 Japanese men with cancer: a decade-long study. Reprod Med Biol 2017; 16 (4): 320–324. doi: 10.1002/rmb2.12044.
33. Maslow AH. A theory of human motivation. Psychol Rev 1943; 50 (4): 370–396. doi: 10.1037/h0054346.
34. Šrámková T. Sexuologie pro zdravotníky. Praha: Galén 2015.
Štítky
Paediatric gastroenterology Gastroenterology and hepatology SurgeryČlánok vyšiel v časopise
Gastroenterology and Hepatology
2019 Číslo 2
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
- Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract
- Obstacle Called Vasospasm: Which Solution Is Most Effective in Microsurgery and How to Pharmacologically Assist It?
Najčítanejšie v tomto čísle
- A gastric Dieulafoy’s lesion
- Involvement of the gastrointestinal tract in amyloidosis: when to think about it and how to diagnose
- Ectopic pancreas as a cause of upper gastrointestinal bleeding
- Inflammatory bowel disease and male fertility