Dysphagia as a symptom of an adverse effect of anticoagulant therapy

Česká verzia

Authors: Kolářová R.
Authors place of work: Endoskopické centrum, Oblastní nemocnice Náchod a. s.
Published in the journal: Gastroent Hepatol 2019; 73(4): 336-338
Category: Clinical and Experimental Gastroenterology: Case Report
doi: https://doi.org/10.14735/amgh2019336

Summary

This case report presents an unusual side effect of dabigatran that can lead to drug-related esophageal mucosal involvement, known as dabigatran-induced esophagitis, manifested by dysphagic problems and typical endoscopic findings, especially in predisposed patients. After discontinuation of dabigatran, clinical problems rapidly resolved and endoscopic findings normalized.

Doručeno/Submitted: 3. 6. 2019

Přijato/Accepted: 23. 7. 2019

MUDr. Renata Kolářová

Endoskopické centrum

Oblastní nemocnice Náchod a. s.

Purkyňova 446

547 01 Náchod

kolarova.renata@nemocnicenachod.cz

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Keywords:

bleeding – esophagitis – dysphagia

Zdroje

1. Duda M, Hildebrand T. Jícen a kardie. In: Mařatka Z et al. Gastroenterologie. 1. vyd. Praha: Karolinum 1999: 53–54.

2. Ootani A, Hayashi Y, Miyagi Y. Dabigatran-induced esophagitis. Clin Gastroenterol Hepatol 2014; 12 (7): e55–e56. doi: 10.1016/j.cgh.2013.09.010.

3. Matsuura H, Suto K, Yasuhara H et al. Longitudinal sloughing mucosal casts: dabigatran-induced oesophagitis. Eur Heart J 2018; 39 (36): 3400. doi: 10.1093/eurheartj/ehy538.

4. Singh S, Savage L, Klein M et al. Severe necrotic oesophageal and gastric ulceration associated with dabigatran. BMJ Case Rep 2013. bcr2013009139. doi: 10.1136/bcr-2013-009139.

5. Wood M, Shaw P. Pradaxa-induced esophageal ulcer. BMJ Case Rep 2015. bcr2015211371. doi: 10.1136/bcr-2015-211371.

6. Kajihara Y. Dabigatran-induced esophagitis. Cleve Clin J Med 2019; 86 (5): 303–304. doi: 10.3949/ccjm.86a.18117.

7. Kajihara Y. Exfoliative esophagitis. Eur J Intern Med 2018; 53: e1. doi: 10.1016/j.ejim.2017.12. 013.

8. European Medicine Agency. SPC Pradaxa. [online]. Dostupné na: https: //www.ema.europa.eu/en/documents/product-information/pradaxa-epar-product-information_cs.pdf.

9. Nyuzuki S, Yamakawa R, Kawauchi K et al. Clinical study of esophagitis induced by dabigatran. [online]. Available from: https: //cdn.ueg.eu/uegfolga-web/uegf-ep-mat088/P1039.pdf.

10. Toya Y, Nakamura S, Tomita K et al. Dabigatran-induced esophagitis: the prevalence and endoscopic characteristics. J Gastroenterol Hepatol 2016; 31 (3): 610–614. doi: 10.1111/jgh.13 024.

11. Katzka DA. Esophageal disorders caused by medications, trauma, and infection. In: Feldman M, Friedman LS, Brandt LJ (eds). Sleisenger and Fordtran’s gastrointestinal and liver disease. 9th ed. Philadelphia: Saunders/Elsevier 2010: 735–737.