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Obesity in children and kidney diseases


Authors: Marinov Z. 1;  Marinová C. 2
Authors place of work: Dětská obezitologická ambulance FN Motol, Praha 1;  Medasol s. r. o., Praha 2
Published in the journal: Gastroent Hepatol 2019; 73(6): 509-516
Category:
doi: https://doi.org/10.14735/amgh2019509

Summary

Chronic kidney disease and non-alcoholic fatty liver disease are global public health concerns. Diabetes, hypertension, and obesity are risk factors for and major contributors to these diseases. Common obesity is frequent in developed countries and is accompanied by chronic metabolic changes. Adipose tissue is the largest endocrine organ in the body, and expansion of this organ results in gradual but extensive cardiometabolic changes due to insulin resistance, proinflammatory status, and endothelial dysfunction, with irreversible central dysregulation of energy homeostasis. The renal and liver effects of common obesity may have their origins in childhood overweight.

Conflict of Interest: The authors declare that the article/manuscript complies with ethical standards, patient anonymity has been respected, and they state that they have no financial, advisory or other commercial interests in relation to the subject matter.

Publication Ethics: This article/manuscript has not been published or is currently being submitted for another review.

The authors agree to publish their name and e-mail in the published article/manuscript.

Dedication: The article/manuscript is not supported by a grant nor has it been created with the support of any company.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted: 2. 12. 2019

Accepted: 5. 12. 2019

Keywords:

children obesity – cardiometabolic risk – programming – non-alcoholic fatty liver disease


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Štítky
Paediatric gastroenterology Gastroenterology and hepatology Surgery

Článok vyšiel v časopise

Gastroenterology and Hepatology

Číslo 6

2019 Číslo 6
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