Obesity in children and kidney diseases
Authors:
Marinov Z. 1; Marinová C. 2
Authors place of work:
Dětská obezitologická ambulance FN Motol, Praha
1; Medasol s. r. o., Praha
2
Published in the journal:
Gastroent Hepatol 2019; 73(6): 509-516
Category:
doi:
https://doi.org/10.14735/amgh2019509
Summary
Chronic kidney disease and non-alcoholic fatty liver disease are global public health concerns. Diabetes, hypertension, and obesity are risk factors for and major contributors to these diseases. Common obesity is frequent in developed countries and is accompanied by chronic metabolic changes. Adipose tissue is the largest endocrine organ in the body, and expansion of this organ results in gradual but extensive cardiometabolic changes due to insulin resistance, proinflammatory status, and endothelial dysfunction, with irreversible central dysregulation of energy homeostasis. The renal and liver effects of common obesity may have their origins in childhood overweight.
Conflict of Interest: The authors declare that the article/manuscript complies with ethical standards, patient anonymity has been respected, and they state that they have no financial, advisory or other commercial interests in relation to the subject matter.
Publication Ethics: This article/manuscript has not been published or is currently being submitted for another review.
The authors agree to publish their name and e-mail in the published article/manuscript.
Dedication: The article/manuscript is not supported by a grant nor has it been created with the support of any company.
The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.
Submitted: 2. 12. 2019
Accepted: 5. 12. 2019
Keywords:
children obesity – cardiometabolic risk – programming – non-alcoholic fatty liver disease
Zdroje
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