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Acute kidney injury in critically ill patients and intestinal dysbio sis


Authors: N. Petejová 1,2;  V. Teplan 1,3,4;  A. Martínek 1;  J. Zadražil 2,5
Authors place of work: Interní a kardiologická klinika LF OU a FN Ostrava 1;  III. interní klinika – nefrologická, revmatologická a endokrinologická, LF UP v Olomouci 2;  Klinické a výzkumné centrum pro střevní záněty, Klinické centrum ISCARE a. s. a 1. LF UK v Praze 3;  Subkatedra nefrologie, IPVZ, Praha 4;  III. interní klinika – nefrologická, revmatologická a endokrinologická, FN Olomouc 5
Published in the journal: Gastroent Hepatol 2024; 78(5): 431-439
Category:
doi: https://doi.org/10.48095/ccgh2024431

Summary

Introduction: Acute kidney injury (AKI) occurs in critically ill patients with significant impact on their morbidity and mortality. The sudden reduction in renal function affects the function of other organs, comprising the intestine, inducing intestinal dysmicrobia, which reciprocally worsens the course of AKI and may also lead to the development of chronic nephropathy. Purpose: Pathophysiology of AKI, sepsis and intestinal dysmicrobia in a critical patient with impact on the development of the disease and other organ systems with possibilities of its positive influence by nutritional measures. Conclusion: Critically ill patients especially in septic status complicated by AKI are prone to complications such as intestinal dysmicrobia, secondary sepsis and immunodeficiency. Treatment of the underlying disease and its complications along with nutritional support helps to improve the clinical outcome of this group of patients.

Keywords:

acute kidney injury – dysmicrobia – intestinal microbiota – sepsis


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ORCID autorů
N. Petejová 0000-0002-5174-5876,
V. Teplan 0000-0001-7717-6686,
A. Martínek 0000-0001-7597-3235,
J. Zadražil 0000-0001-8388-3133.
Doručeno/Submitted: 13. 9. 2024
Přijato/Accepted: 9. 10. 2024
Korespondenční autorka
doc. MUDr. Nadežda Petejová, Ph.D., MSc.
Interní a kardiologická klinika
LF OU a FN Ostrava
17. listopadu 1790/5
708 00 Ostrava 8
petejova@seznam.cz
Štítky
Paediatric gastroenterology Gastroenterology and hepatology Surgery

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Gastroenterology and Hepatology

Číslo 5

2024 Číslo 5
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