Candida biofilms – a current problem of clinical practice

Česká verzia

Authors: E. Boroš ¹; A. Jenča ²
Authors place of work: Oddelenie chirurgie, ŽNsP, Košice, Slovenská republika Primár: MUDr. Erich Boroš ¹; Klinika stomatológie a maxilofaciálnej chirurgie, LF UPJŠ, Košice, Slovenská republika Prednosta: prof. MUDr. Andrej Jenča, CSc. ²
Published in the journal: Prakt. Lék. 2008; 88(12): 695-698
Category: Reviews

Summary

Pathogenic species of the genus Candida are etiological agents of superficial and systemic diseases including nosocomial infections. Many Candida infections are associated with the production of biofilms on surfaces of medicinal implants. The biofilm is a microbially derived sessile community characterized by cells that are irreversibly attached to a substratum or interface or to each other, are embedded in a matrix of extracellular polymeric substances that they have produced, and exhibit an altered phenotype with respect to growth rate and gene transcription. Candida cells of the biofilms are resistant to a broad spectrum of antifungal substances commonly used in clinical practice. The current treatment is based on novel antifungal preparations with anti-biofilm action, for example lipid formulations of amphotericin B and echinocandins (caspofungin and micafungin).

Key words:
Candida, biofilm, resistance.

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