Insights into the pathogenesis of autism spectrum disorders from the molecular and cellular level
Authors:
A. Strunecká 1; R. L. Blaylock 2
Authors place of work:
Laboratoř biochemické neurofarmakologie
Ústavu lékařské biochemie 1. LF UK
Univerzita Karlova, Praha
Přednosta: prof. MUDr. Stanislav Štípek, DrSc.
; Belhaven College, Jackson, Mississippi, USA
2
Published in the journal:
Prakt. Lék. 2008; 88(2): 78-81
Category:
Various Specialization
Summary
Despite the great array of observations, the etiopathogenesis of the autism spectrum disorders (ASD) is poorly defined. Our review offers evidence that most heterogeneous symptoms of ASD might have a common set of pathophysiological events at cellular level closely connected with dysregulation of glutamatergic neurotransmission in the brain with excitotoxicity as a common underlying mechanism. The suggested unifying hypothesis offers the means for efficient prevention and amelioration of ASD.
Key words:
autism, excitotoxicity, glutamatergic neurotransmission, excitatory amino acids.
Zdroje
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Štítky
General practitioner for children and adolescents General practitioner for adultsČlánok vyšiel v časopise
General Practitioner
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