Sarcoidosis- a systemic disease. What is new?

Česká verzia

Authors: M. Vašáková; M. Šterclová; J. Anton
Authors place of work: Primářka: MUDr. Martina Vašáková, Ph. D. ; Fakultní Thomayerova nemocnice s poliklinikou, Praha ; Přednostka: MUDr. Václava Bártů ; Pneumologická klinika 1. LF UK
Published in the journal: Prakt. Lék. 2008; 88(4): 208-212
Category: Various Specialization

Summary

Sarcoidosis, although normally regarded as a pulmonary disease, is, in its nature, a classical systemic disease. From an ethiopathogenetic point of view, the diseases is characterized by non-caseated granuloma formation, which can involve almost all of the organs in the human body, some of them with clinical manifestation and some asymptomatically. In addition to organ involvement the disease also has immunopathologic and metabolic manifestations. Chronic fatigue is considered to be one of the most difficult of the sarcoidosis symptoms to treat. In general, the acute disease with prominent intrathoracic involvement and often with spontaneous regression is prognostically the most favourable form of sarcoidosis. Chronic forms of the disease with prominent extrapulmonary manifestation, usually involving the heart or central nervous system, have much worse prognosis and can be fatal.

The treatment modalities of sarcoidosis comprise mainly of corticosteroids, alternatively antimalaric drugs and immunosuppresives. The biological treatment, targeted against TNF-alpha mediated immunopathologic response, has been recently tried in some cases of the disease.

Key words:
sarcoidosis, granulomas, multiorgan involvement, prognosis, treatment.

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