Autoimmune haemolytic anaemias

Česká verzia

Authors: L. Raida
Authors place of work: Přednosta: Prof. MUDr. Karel Indrák, DrSc. ; Lékařská fakulta Univerzity Palackého a Fakultní nemocnice Olomouc, Hemato-onkologická klinika
Published in the journal: Prakt. Lék. 2011; 91(2): 82-84
Category: Various Specialization

Summary

Autoimmune haemolytic anaemias (AIHA) belong to the acquired diseases with increased consumption of red cells. Autoantibodies bound to the red cells antigens provide an intravascular and/or extravascular haemolysis mediated by monocyte-macrophage system and/or complement. AIHA can be divided into the ones:

1) AIHA with warm-reacting antibodies,

2) AIHA with cold agglutinins,

3) mixed type,

4) paroxysmal cold haemoglobinuria, and

5) drug-related immune haemolytic anaemias.

Except the general markers of haemolysis, the diagnosis is determined by the recognizing of anti-erythrocyte antibodies.

The treatment and its efficacy depend on the type of AIHA. The major aim of therapy is to suppress the activity of autoimmune mechanism leading to the clinically significant haemolysis.

Key words:
autoimmune haemolytic anaemia, anti-erythrocyte autoantibodies, diagnostics, treatment.

Zdroje

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