Gluten enteropathy

Česká verzia

Authors: Z. Mináriková; Z. Bartošová; K. Letková; S. Oravec
Authors place of work: Prednosta: doc. MUDr. Ľudovít Gašpar, CSc. ; II. interná klinika LFUK a UNB Bratislava, Slovensko
Published in the journal: Prakt. Lék. 2012; 92(2): 77-84
Category: Reviews

Summary

Celiac disease is a chronic disease characterized by an immune response to gluten in genetically predisposed patients. Its severe complications may not only increase morbidity and shorten the life of the patient, but also substantially reduce patient quality of life. Through early diagnosis and careful dietary measures it is possible to achieve a resolution of clinical symptoms in a substantial proportion of patients and the incidence of serious complications of the disease can be reduced.

Although the pathogenesis and treatment of the disease is known, and a methodical approach to the diagnosis of celiac disease has been developed and accepted by several professional societies, there are still a large number of patients that escape diagnosis and not only in childhood but mostly in adulthood. It is necessary to bear in mind the wide range of clinical manifestations of celiac disease, which is the result of a complex interaction of various environmental, genetic and immune factors.

Although examination of circulating auto-antibodies in the serum is within the diagnostic algorithm prior to biopsy, especially in the diagnosis of atypical forms, its specificity and sensitivity is not always adequate. It is obvious that the application of targeted screening can help discover new, especially atypical forms of celiac disease, but some will nevertheless remain undiagnosed.

Key words:
celiac disease, gluten, malabsorption, tissue transglutaminase, gluten-free diet, atypical presentations of celiac disease.

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