Up-to-date radiotherapy for prostate cancer
Authors:
P. Čoupek 1; I. Čoupková 1; T. Prochazka 2; P. Šlampa
Authors place of work:
Masarykův onkologický ústav, Brno
Klinika radiační onkologie LF MU
Přednosta: prof. MUDr. Pavel Šlampa, CSc.
1; Oddělení radiologické fyziky
Vedoucí: Ing. Jan Garčic
2
Published in the journal:
Prakt. Lék. 2014; 94(2): 64-68
Category:
Reviews
Summary
Radiotherapy with radical prostatectomy is one of the basic methods of treatment of prostate cancer. Over the last 20 years, radiotherapy for prostate cancer underwent dramatic development. This progress was made possible in particular by introducing computer tomography, and magnetic resonance afterwards, in the planning of radiotherapy and using software to calculate the dose distribution in space. Three-dimensional conformal radiotherapy (3D-CRT) techniques and intensity modulated radiotherapy (IMRT) are associated with a better dose distribution in comparison with conventional techniques and allow the dose escalation without increasing the risk of morbidity. Further advances in technology led to image-guided radiation therapy (IGRT). It is clearly shown that the ability of radiotherapy to cure prostate cancer is dependent on the dose of radiation. Height of dose is an important predictive factor for survival without clinical and biochemical relapse. The higher the delivered dose, the higher the probability of local control. The article highlights also other aspects associated with radiotherapy for prostate cancer, such as brachytherapy, hormonal therapy in combination with radiotherapy, postoperative radiotherapy after RAPE, hypofractionation, stereotactic radiotherapy and proton beam therapy.
Keywords:
prostate cancer – radiotherapy – hormonal therapy – sequelae of radiotherapy
Zdroje
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