Elevated lipoprotein-associated phospholipase A2 in geriatric patients

Česká verzia

Authors: MUDr. Jo O Fortunato ¹; MUDr. Michaela Fortunato ¹; prof. MUDr. Vladimír Blaha, CSc. ¹; MUDr. Josef Bis, Ph.D. ²; doc. RNDr. Ctirad Andrýs, Ph.D. ³; MUDr. Božena Jurašková, Ph.D. ¹; prof. MUDr. Luboš Sobotka, CSc. ¹
Authors place of work: III. interní gerontometabolická klinika, FN Hradec Králové ¹; I. interní karioangiologická klinika, FN Hradec Králové ²; Ústav klinické imunologie a alergologie, FN Hradec Králové ³
Published in the journal: Geriatrie a Gerontologie 2020, 9, č. 2: 97-100
Category: Original Article

Summary

Lipoprotein-associated phospholipase A2 (Lp-PLA₂) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA₂ mass between them.

Methods: 44 patients aged 79.6 ± 5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n = 35) or BA (n = 9). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA₂ mass was measured using an enzyme- linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure.

Results: Lp-PLA₂ mass was significantly elevated in this population (1296 ± 358 ng/mL before TAVI; 1413 ± 268 ng/mL before BA) and further increased after TAVI (1604 ± 437 ng/mL, P < 0.01) or BA (1808 ± 303 ng/mL, P < 0.01). Lp-PLA₂ mass was significantly increased on the diabetic group before these interventions.

Conclusion: Lp-PLA₂ may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA₂ in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.

Keywords:

Atherosclerosis – diabetes mellitus – transcatheter implantation – Aortic valve – aortic stenosis – balloon angioplasty – Lipoprotein associated phospholipase

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