Immunoendocrine associations in adrenal glands

Česká verzia

Authors: I. Šterzl; P. Hrdá
Authors place of work: Endokrinologický ústav Praha, ředitel doc. MUDr. Vojtěch Hainer, CSc.
Published in the journal: Vnitř Lék 2010; 56(12): 1286-1291
Category: Celebration

Summary

Immune and endocrine systems are basic regulatory mechanisms of organism and, including the nervous system, maintain the organism’s homeostasis. The main immune system representatives are mononuclear cells, T‑ and B‑ cells and their products, in the endocrine system the main representatives are cells of the glands with inner secretion and their products. One of the most important glands for maintaining homeostasis are adrenal glands. It has been proven that either cells of the immune system, either endocrine cells can, although in trace amounts, produce mutually mediators of both systems (hormones, cytokines). Disorders in one system can lead to pathological symptoms in the other system. Also here represent adrenals an important model.

Key words:
adrenal glands – Addison’s disease – lymphocytes – cytokines – glucocorticoids – autoantibodies – autoantigens

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