Changes to calcium-phosphate metabolism associated with chronic nephropathies

Česká verzia

Authors: J. Blahoš ¹; I. Sotorník ^1,2
Authors place of work: Oddělení klinické endokrinologie a osteocentrum Ústřední vojenské nemocnice Praha, vedoucí prof. MUDr. Jaroslav Blahoš, DrSc. ¹; Osteologická ambulance Synlab Czech, Praha, vedoucí lékařka MUDr. Kateřina Kotrčová, Ph. D. ²
Published in the journal: Vnitř Lék 2012; 58(7 a 8): 12-18
Category: 80th Birthday MUDr. Miroslav Mydlík, DrSc.

Summary

The paper discusses bone mineral and bone disorders associated with chronic nephropathies that are a logical consequence of reduced renal function. These are principally driven by changes in parathormone production and vitamin D synthesis. Bones are usually affected by renal osteopathy – osteodystrophy with abnormities of bone turnover, mineralization and volume, and with growth retardation in children. Extra-skeletal calcifications may occur, of which vascular wall localization is the most serious. A collection of pathologies develops, now termed chronic kidney disease – mineral and bone disorder (CKD-MBD).

Key words:
bone minerals – chronic nephropathy – parathormone – vitamin D – skeletal changes – calcification

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