Oxidative stress and antioxidation systems in haemodialyzed patients

Česká verzia

Authors: O. Rácz ^1,2; M. Mydlík ³; A. Chmelárová ³; K. Derzsiová ¹; D. Maceková ¹; F. Ništiar ¹; E. Lovásová ¹; B. Fodor ²
Authors place of work: Ústav patologickej fyziológie Lekárskej fakulty UPJŠ Košice, Slovenská republika, prednosta prof. MUDr. Oliver Rácz, CSc. ¹; Institute of Nanobiotechnology and Regenerative Medicine, Miskolc University, Hungary, head Fodor Bertalan, MSc, PhD, EurClinChem ²; Ústav experimentálnej medicíny Lekárskej fakulty UPJŠ, Košice, Slovenská republika, prednosta MVDr. Alojz Bomba, DrSc. ³
Published in the journal: Vnitř Lék 2012; 58(7 a 8): 71-74
Category: 80th Birthday MUDr. Miroslav Mydlík, DrSc.

Summary

The authors present a critical analysis of current knowledge on oxidative stress and on the activity of antioxidative systems in patients with chronic kidney disease with a focus on haemodialysed patients. Even though oxidative stress in these patients is well documented, a number of questions remain unanswered. The overview describes pathobiochemistry of oxidative stress during haemodialysis, analysis of current knowledge on lipid peroxidation and antioxidant enzyme activity in the red blood cells in patients with this disease. Finally, the authors evaluate opinions on justifiability of exogenous supplementation of vitamins with antioxidant properties in patients on haemodialysis. They conclude that the use of vitamin E-containing membranes is the only evidenced option for reducing oxidative stress during haemodialysis.

Key words:
chronic kidney disease – haemodialysis – oxidative stress – antioxidative systems

Zdroje

1. Giardini O, Taccone-Gallucci M, Lubrano R et al. Evidence of red blood cell membrane lipid peroxidation in haemodialysis patients. Nephron 1984; 36: 234–237.

2. Jackson P, Loughren CM, Lightbody JH et al. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. Clin Chem 1995; 41: 1135–1138.

3. Himmelfarb J, Ikizler TA, Stenwinkel P et al. The elephant in uraemia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002; 62: 1524–1538.

4. Locatelli F, Canaud B, Eckardt KU et al. Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant 2003; 18: 1272–1280.

5. Handelman GJ. Current studies on oxidant stress in dialysis. Blood Purification 2003; 21: 46–50.

6. Westhuyzen J, Saltissi D, Stanbury V. Oxidative stress and erythrocyte integrity in end-stage renal failure patients hemodialysed using a vitamin E-modified membrane. Ann Clin Lab Sci 2003; 33: 3–10.

7. Mircescu G, Capusa C, Stoain I et al. Global assessment of serum antioxidant status in hemodialysis patients. J Nephrol 2005; 18: 559–605.

8. de Vecchi AF, Bamonti F, Novembrino C et al. Free and total plasma malondialdehyde in chronic renal insufficency and in dialysis patients. Nephrol Dialysis Transplant 2009; 24: 3532–3538.

9. Li RY. Free radicals and related reactive species in renal diseases. In: Li RY. Free Radical Biomedicine: Principles, Clinical Correlations, and methodologies. Bentham Science 2012: 202–216.

10. Hoelzl C, Bichler J, Ferk F et al. Methods for the detection of antioxidants which prevent age related diseases: A critical review with particular emphasis on human intervention studies. J Physiol Pharmacol 2005; 56 (Suppl 2): 49–64.

11. Li RY. Detection of damage of biomolecules by free radicals and related reactive species. In: Li RY (ed.). Free Radical Biomedicine: Principles, Clinical Correlations, and methodologies. Bentham Science 2012: 295–306.

12. Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol 2003; 15: 247–254.

13. Preiser JC. Oxidative stress. J Parenter Enteral Nutr 2012; 36(2): 147–154.

14. Jakuš V, Rietbock N. Intermediárne a koncové produkty neenzýmovej glykácie. Chem Listy 1999; 93: 375–381.

15. Oigino K, Wang DH. Biomarkers of oxidative/nitrosative stress: an approach to disease prevention. Acta Med Okayama 2007; 61: 181–189.

16. Lovásová K, Lovásová E, Rácz O et al. Oxid dusnatý opäť v popredí pozornosti – nový pohľad na diabetické komplikácie kardiovaskulárneho systému. In: Patofyziologie 2008. Sborník příspěvků 17. konference Českých a slovenských patofyziologů. 1. LF UK: 48.

17. Mydlík M, Derzsiová K, Šipulová A et al. A modified dialyzer with vitamin E and antioxidant defense parameters. Kidney International 2001; 59 (Suppl 78): S144–S147.

18. Mydlík M, Derzsiová K, Rácz O et al. Vitamin E-coated dialyzer and antioxidant defense parameters: Three-month study. Seminars Nephrol 2004; 24: 525–531.

19. Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agricult Food Chem 2005; 53: 1841–1856.

20. Malliaraki N, Mpliamplias D, Kampa M et al. Total and corrected antioxidant capacity in hemodialyzed patients. BMC Nephrology 2003; 4: 1–8.

21. Scurati-Manzoni E, Cighetti G. Free and total malondialdehyde in chronic renal insufficiency and in dialysis patients. Nephrol Dialys Transplant 2009; 24: 2524–2529.

22. Mydlík M, Derzsiová K, Rácz O et al. Vitamin E as an antioxidant agent in CAPD patients. Int J Artificial Organs 2002; 25: 373–378.

23. Giray B, Kan E, Bali M et al. The effect of vitamin E supplementation on antioxidant enzyme activities and lipid peroxidation levels in hemodialysis patients. Clin Chim Acta 2003; 338: 91–98.

24. Montazerifar F, Hashemi M, Karajibani M et al. Effect of combined vitamins C and E supplementation on oxidant/antioxidant status in hemodialysis patients. Mediterr J Nutr Metab 2010; 3: 159–163.

25. Antoniadi G, Eleftheriadis T, Liakopoluos V et al. Effect of one-year oral alpha-tocopherol administration on the antioxidant defense system in hemodialysis patients. Therap Apheresis Dialysis 2008; 12: 237–242.

26. Šipulová A, Rácz O. Hodnotenie a modifikácia metódy Ransod. Lab Diagnost 1997; 2: 144–148.

27. Gordon CA, Himmelfarb J. Antioxidant therapy in uremia: Evidence-based medicine? Seminars Dialysis 2004; 17: 327–332.

28. Sasaki M. Development of vitamin E-modified polysulfone membrane dialyzers. J Artificial Org 2006; 9: 50–60.

29. Libetta C, Zucchi M, Gori E et al. Vitamin E-loaded dialyzer resets PBMC-operated cytokine network. Kidney Int 2004; 65: 1473–1481.

30. Kojima K, Oda K, Homma H et al. Effect of vitamin E-bonded dialyzer on eosinophilia. Nephrol Dialysis Transplant 2005; 20: 1932–1935.

31. Yang CC, Hsu SP, Wu M et al. Effects of vitamin C infusion and vitamin E-coated membrane in hemodialysis-induced oxidative stress. Kidney Internat 2006; 69: 706–714.

32. Sosa MA, Balk EM, Lal J et al. A systematic review of the effect of the Excebrane dialyzer on biomarkers of lipid peroxidation. Nephrol Dialys Transplant 2006; 21: 2825–2833.

33. Banche G, Allizond V, Giacchino F et al. Effect of dialysis membrane biocompatibility on polymorphonuclear granulocyte activity in dialysis patients. Nephrol Dialys Transplant 2006; 21: 3532–3538.

34. Takouli L, Hadjiyannakos D, Metaxaki P et al. Vitamin E-coated cellulose acetate dialysis membrane: Long-term effect on inflammation and oxidative stress. Renal Failure 2010; 32: 287–293.

35. Vostálová J, Galandáková A, Štrebl P et al. Oxidační stres u pacientů s onemocněním ledvin. Vnitř Lék 2012; 58: 202–207.