Importance of lymphangiogenesis and ultrastructure of lymphatic capillaries in metastasis of malignant melanoma

Česká verzia

Authors: Eva Rovenská
Authors place of work: Klinika chirurgickej onkológie Slovenskej zdravotníckej univerzity a Národného onkologického ústavu, Bratislava, Slovenská republika, prednosta prof. MUDr. Juraj Pechan, CSc.
Published in the journal: Vnitř Lék 2014; 60(7-8): 582-585
Category: Reviews

Summary

Lymphangiogenesis – proliferation of lymphatic capillaries – in melanoma and in its vicinity plays an important role in metastatic process of malign melanoma cells in organism. Melanoma produces epidermal growth factor EGF which induces vascular endothelial growth factor VEGF-C and thereby starts lymphangiogenesis. It is very probable that malignant melanoma cells enter lymphatic capillaries also through specialized inter-endothelial junctions (endothelial microvalves, primary valves) situated in their walls. After entry of malign cells into lymphatic capillaries, these cells travel in lymph to the sentinel lymph node. Malign cells metastasize through lymphatic vessels probably also directly into distal regional lymphatic nodes. Metastasizing through blood vessels is suggestible also in early stage melanoma.

Key words:
lymphangiogenesis – malignant melanoma – sentinel lymph node

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