New antibiotics: do we need new molecules or new strategies?

Česká verzia

Authors: Vladimír Krčméry ^1,2; Naďa Kulková ³
Authors place of work: Slovenský tropický inštitút, VŠ zdravotníctva a sociálnej práce Sv. Alžbety, Bratislava, Slovenská republika, vedúci pracovník prof. MUDr. Vladimír Krčméry, Dr. Sc., FRCP, FACP. ¹; Mikrobiologický ústav LF UK a UN Bratislava, Slovenská republika, vedúci prof. MUDr. Vladimír Krčméry, DrSc., FRCP, FACP ²; Laboratórium molekulárnej mikrobiológie - spoločné výskumné pracovisko FZaSP TU a VŠ ZaSP sv. Alžbety, Bratislava, Slovenská republika, vedúci prof. MUDr. Vladimír Krčméry, Dr. Sc., FRCP, FACP ³
Published in the journal: Vnitř Lék 2014; 60(Suppl 2): 40-45
Category: 70th Birthday - prof. MUDr. Jiří Vorlíček, CSc.

Summary

Even though the situation in the field of research and development of new antimicrobial agents is not ideal, the years of stagnation, especially among anti-gramnegative agents, seem to be over. During the years 2011–2012 we have witnessed a movement towards a development of some new antibiotic agents not only with anti-grampositive activity but with anti-gramnegative too, as well as new antituberculotics and antifungals. Here we present some of these new antiinfectives, presented in conferences during the last year, of which many are being shifted to the level of clinical trials of phase II–III, while others are in stage of preclinical studies.

Keywords:
antibiotics – antimycotics – antituberculotics

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