Vitamin D₃ supplementation and cellular calcium homeostasis in patients with chronic kidney disease

Česká verzia

Authors: Ingrid Lajdová; Adrián Okša; Viera Spustová
Authors place of work: Ústav farmakológie, klinickej a experimentálnej farmakológie LF SZU, Bratislava, Slovenská republika
Published in the journal: Vnitř Lék 2016; 62(Suppl 6): 40-45
Category: Reviews

Summary

Mini review summarizes the results of our studies focused on elucidation of the pathophysiological mechanisms of altered calcium homeostasis in nonexcitable cells from patients with early stages of chronic kidney disease (CKD), as well as on determining the effect of vitamin D₃supplementation on these mechanisms. The basic mechanisms of calcium entry to and removal of the cell are already changed in early stages of CKD. These disturbances cause an increased the concentration of cytosolic free calcium ([Ca²⁺]_i), which may change a number of cellular processes, and the expression of various signaling molecules. Vitamin D₃ supplementation is a standard procedure of vitamin D insufficiency/ deficiency correction in these patients. The pleiotropic effects of vitamin D may be involved in the modulation of cellular calcium homeostasis. Vitamin D₃ supplementation resulted in a reduction in [Ca²⁺]_i by affecting of specific transport systems of calcium cations entry to and removal of the cell. The normalization [Ca²⁺]_i can have a beneficial effect on intracellular signalling, and thus positively influence the functioning of cells, tissues or organs.

Key words:
cellular calcium homeostasis – chronic kidney disease – intracellular calcium – vitamin D

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