Endothelial Responses to Hypoxia
REAKCE ENDOTELU NA HYPOXII
Během posledních let došlo k rychlému rozvoji poznatků na poli cévní biologie a byla objasněna aktivní roleendotelu v regulaci homeostázy. Článek podává stručný přehled nových znalostí z biologie endotelu se zaměřenímna teorii aktivace/dysfunkce endotelu při hypoxii. Uvedeny jsou současné možnosti praktického využití základníhovýzkumu v této oblasti a příklady stavů, ve kterých hraje aktivace endotelu klíčovou roli v patogeneze onemocnění.
Klíčová slova:
hypoxie, endotel, aktivace/dysfunkce.
Authors:
A. Karimová
Authors‘ workplace:
Klinika dětského a dorostového lékařství 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2000; : 295-298
Category:
Overview
In the last decade endothelium was shown to play an active role in regulating vascular homeostasis. This reviewfocuses on the endothelial reactions during pathological condition of hypoxia. Cascade of events leading toendothelial activation/dysfunction during hypoxia is described and consequences of our expanded understanding ofvascular biology for current clinical practice are summarised.
Key words:
hypoxia, endothelium, activation/dysfunction.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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