Essential Hypertension – Syndrome, or Compensatory Mechanism
Authors:
I. Hulín; I. Ďuriš; E. Sapáková; Ľ. Paulis; B. Mravec
Authors place of work:
Ústav experimentálnej endokrinológie SAV, Bratislava, Slovenská republika
; I. interná klinika FN a LF UK, Bratislava, Slovenská republika
; Ústav patologickej fyziológie LF UK, Bratislava, Slovenská republika
Published in the journal:
Čas. Lék. čes. 2008; 147: 14-24
Category:
Review Article
Summary
Diagnosis of essential hypertension is created per exclusionem – with exclusion of all, so called secondary hypertensions (nephrogenic, endocrine conditioned etc). Idea and the name-essential hypertension are unclear. We have a lot of hypotheses about mechanisms of hypertension but no one is explaining satisfactorily the „fixation“ of hypertension. From this point of view essential hypertension looks more like a syndrome than disease sui generis. Authors analyzed all possible pathways of hypertension origin as well as compensatory mechanisms in peripheral circulation in effort to reach relevant tissue perfusion. If these mechanisms lead to salt and water retention the best mode of the treatment would be to influence volume and blood vessels lumen. It is clear that optimization of blood pressure is advantageous for prevention of vascular catastrophes (myocardial and cerebral infarction). Nevertheless inadequate lowering of the peripheral tissue perfusion (kidney, CNS) can lead to degenerative changes in tissues and to disturbances in centrally regulated processes of blood pressure.
Key words:
beneficial hypertension, holistic view, capillary flow, kidney, sodium, stress, sympathetic nervous system.
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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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