Peripheral Nerve Injury and the Degree of Motor Involvement in Parkinson’s Disease: A Correlation Study
Authors:
Z. Chovancová 1; P. Kaňovský 1; I. Nestrašil 1; J. Dufek 2; M. Nevrlý 1; P. Otruba 1
Authors place of work:
Neurologická klinika LF UP a FN – Centrum pro diagnostiku a léčbu neurodegenerativních onemocnění, Olomouc
1; Privátní poliklinika Dr. Kropáče, neurofyziologická laboratoř, Brno
2
Published in the journal:
Čas. Lék. čes. 2008; 147: 211-214
Category:
Original Article
Summary
Background.
The aim of the study was to validate a hypothesis about the presence of a concomitant peripheral nerves injury in patients suffering from neurodegenerative disorders. The study was focused on the correlation between motor involvement in Parkinson’s disease and peripheral nerves injury.
Methods and Results.
23 patients suffering from Parkinson’s disease, which was diagnosed in terms of strict UK-PDBB criteria, were examined. There were 14 men (mean age: 57 years, mean age at the disease onset: 51years, mean disease duration: 7 years, mean duration of dopaminergic treatment: 4 years) and 9 women (mean age: 67 years, mean age at the disease onset: 63 years, mean duration of disease: 4 years, mean duration of dopaminergic treatment: 1 year). Polyneuropathy was clinically present and confirmed using EMG examination in 10 patients (43.5 %), 5 men and 5 women.
Conclusions.
Our observation indicates that the neurodegenerative process can be involved not only in the degeneration of central nervous system, but also in the peripheral disorders in this population.
Key words:
Parkinson’s disease, polyneuropathy, electromyography, correlation.
Zdroje
1. Braak, H., Del Tredici, K., Rub, U. et al.: Staging of brain pathology related to sporadic Parkinsons disease: Neurobiology of aging, 2003, 24, s. 197–211.
2. Abbruzzesse, G., Pigullo, S., Schenone, A. et al.: Does parkin play a role in a peripheral nervous system? A family report. Mov. Disord., 2004, 18, s. 978–981.
3. Rodolico, C., Toscano, A., De Luca, G. et al.: Peripheral neuropathy as the presenting features of multiple system atrophy. Clin. Autonom. Res., 2001, 11, s. 63.
4. Taly, A. B., Mutane, U. B.: Involvement of peripheral nervous system in juvenile Parkinsonęs disease. Acta Neurol. Scand., 1992, 85, s. 272–275.
5. Abele, M., Schulz, J. B., Burk, K. et al.: Nerve conduction studies in multiple system atrophy. Eur. Neurol., 2000, 43, s. 221–223.
6. Becker, G., Muller, A., Braune, S. et al.: Early diagnosis of Parkinsonęs disease. J. Neurol., 2002, 249 (Suppl. 3), s. 40–48.
7. Bareš, M., Kaňovský, P., Rektor, I.: Disturbed intracortical excitability in early Parkinsonęs disease is L-DOPA related: a prospective 12-month paired TMS study. Parkinsonism Relat. Disord., 2007, 13, 520–526
8. Hoehn, M. M., Mahr, M. D.: Parkinsonism, s. onset, progression and mortality Neurology, 1967, 17, s. 427–442.
9. Tolosa, E., Wenning, G., Poewe, W.: The diagnosis of Parkinson’s disease. Lancet Neurol., 2006, 5, s. 75–86.
10. Chovancová, Z., Kaňovský, P., Nestrašil, I., Dufek, J.: Peripheral nerves injury in the central nervous system degeneration: pilot study (abstract). Movement Disorders, 2006, 21 (Suppl. 15), s. S362–S363.
11. Nevrlý, M., Vranová, H., Ressner, P. et al.: Effect of levodopa and entacapone treatment on plasma homocystein level in Parkinson Disease: pilot study (abstract) Movement Disorders, 2006, 21 (Suppl. 15), s. S545.
12. Hallett, M. et al.: Handbook of clinical Neurophysiology, Vol 1, Movement disorders, 1st Edition, Philadelphia, Elsevier 2003, s. 7–19.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
Journal of Czech Physicians
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Metamizole vs. Tramadol in Postoperative Analgesia
- Spasmolytic Effect of Metamizole
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
Najčítanejšie v tomto čísle
- Risk Factors of Atelectasis Following Pulmonary Lobectomy
- Somatostatin Analogues in the Treatment of Carcinoid
- Sacral Nerve Stimulation in the Treatment of Anal Incontinence
- Peripheral Nerve Injury and the Degree of Motor Involvement in Parkinson’s Disease: A Correlation Study