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Therapy of Chronic Myeloid Leukemia. Uncommon View of the Modern Approaches


Authors: J. Mayer 1;  D. Žáčková 1;  H. Klamová 2;  M. Doubek 1
Authors place of work: Interní hematoonkologická klinika FN, Brno 1;  Ústav hematologie a krevní transfuze, Praha Česká leukemická skupina – pro život (The CzEch Leukemia Study Group – for Life, CELL) 2
Published in the journal: Čas. Lék. čes. 2008; 147: 206-210
Category: Review Article

Summary

Chronic myeloid leukemia has got an outstanding position among the other oncology diseases, particularly due to specific chromosomal abnormality called Philadelphia chromosome, its molecular consequence BCR/ABL fusion gene and its biologic product BCR/ABL tyrosinekinase, which is responsible for the leukemic transformation of the hematopoetic cells. We can see a real revolution in the treatment of the chronic myeloid leukemia in the last few years. The authors pay attention to the developement of the new drugs in the large historical consequences from the beginning in the 19th century (describing leukemia first time) to the introduction of the new small specific molecules into the clinical practice.

Key words:
chronic myeloid leukemia, tyrosinkinase, BCR/ABL, targeted therapy.


Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Článok vyšiel v časopise

Journal of Czech Physicians

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