Kidney transplantation at the Institute for Clinical and Experimental Medicine
Authors:
Ondřej Viklický; Janka Slatinská; Marcela Bürgelová; Štefan Vítko; Mariana Urbanová; Renáta Lažanská; Vladimír Hanzal; Štěpán Bandúr; Vladimír Teplan; Ivo Matl; Libor Janoušek; Eva Honsová; Monika Drastichová; Jan Malý
Authors place of work:
Institut klinické a experimentální medicíny Praha, Transplantační centrum, Klinika nefrologie
Published in the journal:
Čas. Lék. čes. 2011; 150: 56-59
Category:
Original Article
Summary
Background:
Kidney transplantation represents the method of choice of end stage renal disease.
Methods and results:
The program of kidney transplantation was established in 1966 in our centre. In recent years, roughly 200 patients have undergone kidney transplantation annually, and 20–30 of them have received a graft from the living donor. Triple immunosuppressive regimen based on tacrolimus, MMF and steroids is given to majority of patients, in a case of high rejection risk; patients have received the induction protocols with polyclonal or monoclonal antilymphocyte globulins. Acute rejection is not a frequent finding in recent years and has occurred in 15% of cases in the first 3 months, the use of induction immunosuppression has decreased the rejection risk. Valgancyclovir has been used as prophylactic agent to prevent and treat cytomegalovirus infection. The usage of this strategy reduced the incidence of CMV infection below 10%. Kidney transplant recipients suffer from similar comorbidities as other renal patients in the long term, as cardiovascular complications, infections and malignancies. Anemia is a frequent complication in patients with graft dysfunction and erythropoesis stimulating agents have been used in its therapy. The median kidney graft survival is 8 years.
Conclusions:
Kidney transplantation is associated with better long-term results when compared with dialysis therapy and thus this method should be offered to all of suitable end stage renal disease patients.
Key words:
end stage renal disease, kidney transplantation, immunosuppression, complications.
Zdroje
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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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