Determination of liver triglycerides by 1H MR spectroscopy
Authors:
Milan Hájek 1; Monika Dezortová 1; Dita Wagnerová 1; Luděk Voska 2; Irena Hejlová 3; Pavel Trunečka 3
Authors place of work:
Institut klinické a experimentální medicíny Praha, MR spektroskopie, Základna radiodiagnostiky a intervenční radiologie
1; Institut klinické a experimentální medicíny Praha, Pracoviště klinické a transplantační patologie
2; Institut klinické a experimentální medicíny Praha, Klinika hepatogastroenterologie
3
Published in the journal:
Čas. Lék. čes. 2011; 150: 68-71
Category:
Original Article
Summary
Background:
Metabolic syndrome is responsible for increasing the fat content of the liver. Among several non-invasive methods of liver fat analysis, the most important role is played by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). This pilot study describes the methodology for measurements of triglycerides in the liver in a group of liver transplant patients using 1H MRS at 3T.
Methods and results:
Thirty-eight patients (12 female, 27 male, aged 19–71) who underwent routine preventive examination at IKEM were included in the MRS study. The fat content of liver biopsies was classified according to the number of affected hepatocytes, HIS. Based on this classification, there were 20 patients with a steatosis score of S0, 15 patients with a score of S1, 2 patients with a score of S2 and 1 patient with a score of S3. 1H MR spectra were measured from three positions in the liver. Following Longo et al, the concentration of fat φfat was calculated from the signal intensities of water and triglycerides. Linear correlation between the number of affected hepatocytes and fat content was described by the equation: HIS = 6.4 φfat –2.1; r2 = 0.85; p = 0.001.
Conclusions:
The pilot study confirmed that examination of fat content using 1H MRS at 3T is well tolerated by patients. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive and screening examination measurement of fat in the liver.
Key words:
metabolic syndrome, liver steatosis, determination of triglycerides, 1H MR spectroscopy.
Zdroje
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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
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