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Vitamin D: Its physiology, pathophysiology and significance in etiopathogenesis of malignant diseases


Authors: Klára Drábová 1;  Julie Bienertová-Vašků 1,2;  Petr Lokaj 1;  Lenka Dubská 3,4;  Radka Obermannová 5;  Kristína Greplová 3;  Regina Demlová 4,6;  Dalibor Valík 3,4;  Jaroslav Štěrba 1
Authors place of work: Klinika dětské onkologie, Fakultní nemocnice, Brno 1;  Ústav patologické fyziologie, Lékařská fakulta, Masarykova univerzita, Brno 2;  Oddělení laboratorní medicíny, Masarykův onkologický ústav, Brno 3;  Farmakologický ústav, Lékařská fakulta, Masarykova univerzita, Brno 4;  Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno 5;  Oddělení klinických hodnocení, Masarykův onkologický ústav, Brno 6
Published in the journal: Čas. Lék. čes. 2013; 152: 20-30
Category: Review Article

Summary

Vitamin D is an endogenous product of mammalian organisms from which an active agent of a steroid hormone nature is synthesized. These hormones participate in a variety of key metabolic processes in every nuclear cell, whether on endocrine, paracrine and autocrine or subcellular level. Vitamin D represents a very interesting molecule which participates in a great deal of body processes. This review summarizes the findings about the metabolism of vitamin D focusing on pathophysiology of malignant diseases.

Keywords:
vitamin D – malignant diseases – metabolism of vitamin D – anticancer effects of vitamin D


Zdroje

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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