Early detection of sporadic pancreatic cancer
Authors:
prof. MUDr. Přemysl Frič, DrSc. 1; prof. MUDr. Aleksi Šedo, DrSc. 2; prof. MUDr. Jan Škrha, DrSc. 3; Mba; prof. MUDr. Tomáš Zima, DrSc. 4; Mba; MUDr. Petr Bušek, Ph.D. 2; MUDr. Pavel Škrha 5; MUDr. Klára Kmochová, Ph.D. 1; MUDr. Martin Laclav 1; MUDr. Bohuš Bunganič 1; prof. MUDr. Miroslav 1; Zavoral, Ph.D.
Authors place of work:
Interní klinika 1. LF UK a ÚVN – Vojenské fakultní nemocnice, Praha
1; Ústav biochemie a experimentální onkologie 1. LF UK v Praze.
2; 3. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a
VFN v Praze
3; Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN v
Praze
4; 2. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
5
Published in the journal:
Čas. Lék. čes. 2016; 155: 44-47
Category:
Review Articles
Summary
Pancreatic cancer (PC) behaves very differently in comparison with other malignancies. Its prevalence continuously increases, mortality does not decrease, diagnosis is frequently late, radical surgery is limited to 15–20 % of patients, postoperative relapses are frequent, and chemotherapy has a palliative character. Preventive programs are the only possibility of improvement. In familial pancreatic cancer (FPC) the knowledge of the genetic mutation enables earlier entry of specialists into the surveillance program. The repeated use of high resolution imaging methods (including endoscopy and pancreatic cytology) may be followed by more frequent detection of the precursors and earlier stages of FPC. The identification of sporadic pancreatic cancer (SPC) depends fully on the construction of a multi-step and multi-disciplinary preventive program.
Keywords:
sporadic pancreatic cancer, risk factors, pancreatogenic diabetes, early symptoms, early detection, risk groups
Zdroje
1. Ferlay E, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality world-wide: sources, methods and major patterns in Globocan 2012. Int J Cancer 2015; 136: E359–E386.
2. Chari ST, Kelly K, Hollingsworth MA et al. Early detection of sporadic pancreatic cancer: summative review. Pancreas 2015; 44: 693–712.
3. Rahib L, Smith BD, Aizenberg R et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver and pancreas cancer in the United States. Cancer Res 2014; 74: 2913–2921.
4. Yachida S, Jones S, Bozic I et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467: 1114–1117.
5. Aggarwall G, Kamada P, Chari ST. Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers. Pancreas 2013; 42: 198–201.
6. Li C, Balluz LS, Ford ES et al. Association between diagnosed diabetes and self reported cancer among US adults. Findings from the 2009 Behavioral risk factor surveillance system. Diabetes Care 2011; 34: 1365–1368.
7. Li D: Diabetes and pancreatic cancer. Mol Carcinog 2012; 51: 64–74.
8. Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA 1995; 273: 1605–09.
9. Wang F, Herrington M, Larsson J et al. The relationship between diabetes and pancreatic cancer. Mol Cancer 2003; 2: 4.
10. Huxley R, Ansary-Moghaddam A, Berrington de González A et al. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 2005; 92: 2076–2083.
11. Muniraj T, Chari ST. Diabetes and pancreatic cancer. Minerva Gastroenterol Dietol 2012; 58: 331–345.
12. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34(Suppl. 1): S62–S69.
13. Cui YF, Andersen DK. Diabetes and pancreatic cancer. Endocr Relat Cancer 2012; 19: F9–F26.
14. Ewald N, Bretzel RG. Diabetes mellitus secondary to pancreatic diseases (Type 3c) – are we neglecting an important disease? Eur J Intern Med 2013; 24: 203–206.
15. Aggarwal G, Ramachandran V, Javeed N et al. Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in beta-cells and mice. Gastroenterology 2012; 143: 1510–1517.
16. Sah RP, Nagpal SJ, Mukhopadhyay D et al. New insights into pancreatic cancer induced paraneoplastic diabetes. Nat Rev Gastroenterol Hepatol 2013; 10: 423–433.
17. Hart PA, Kamada P, Rabe KG et al. Weight loss precedes cancer specific symptoms in pancreatic cancer-associated diabetes mellitus. Pancreas 2011; 40: 768–72.
18. Girelli CM, Reguzzoni G, Limido E et al. Pancreatic carcinoma differences between patients with or without diabetes. Recenti Prog Med 1995; 86: 143–146.
19. Damiano J, Bordier L, Le Berre JP et al. Should pancreas imaging be recommended in patients over 50 years when diabetes is discovered because of acute symptoms? Diabetes Metab 2004; 30: 203–207.
20. Cui Y, Andersen DK. Pancreatogenic diabetes: special considerations for management. Pancreatology 2011; 11: 279–294.
21. Andersen DK, Andren-Sandberg A, Duell EJ et al. Pancreatitis-diabetes-pancreatic cancer: summary of a NIDDK-NCI workshop. Pancreas 2013; 42: 1227–1237.
22. Hart PA., Baichoo E, Bi Y et al. Pancreatic polypeptide response to a mixed meal is blunted in pancreatic head cancer associated with diabetes mellitus. Pancreatology 2015; 15: 162–166.
23. Okano, K, Suzuki Y. Strategies for early detection of resectable pancreatic cancer. World J Gastroenterol 2014; 20: 11230–11240.
24. Fusari M, Mavrea S, Imbriaco N et al. Comparison between multi-slice CT and MR-imaging in diagnostic evaluation of patients with pancreatic cancer. Radiol Med 2010; 115: 453–466.
25. Mikata R, Ushihara T, Tada M et al. Clinical usefulness of repeated pancreatic juice cytology via endoscopic nasopancreatic drainage tube in patients with pancreatic cancer. J Gastroenterol 2012; 48: 866–873.
26. Iboshi T, Hanada K, Fukuda T. Value of cytodiagnosis using endoscopic nasopancreatic drainage for early diagnosis of pancreatic cancer. Pancreas 2012; 41: 523–529.
27. Hanada K, Okazaki A, Hirano N et al. Diagnostic strategies for early pancreatic cancer. J Gastroenterol 2015; 50: 147–154.
28. Egawa S, Toma H, Ohigashi et al. Japan Pancreatic Cancer Registry, 30 year anniversary. Japan Pancreas Society. Pancreas 2012; 41: 985–992.
29. Kenner BJ, Chari ST, Cleeter DE et al. Early detection of sporadic pancreatic cancer. Strategic map for innovation – A white paper. Pancreas 2015; 44: 686–692.
Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
Journal of Czech Physicians
- Advances in the Treatment of Myasthenia Gravis on the Horizon
- Spasmolytic Effect of Metamizole
- Metamizole at a Glance and in Practice – Effective Non-Opioid Analgesic for All Ages
- What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
- Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
Najčítanejšie v tomto čísle
- Pancreatic cancer – current effective diagnostic and therapeutic approach
- Malignant biliary obstruction
- Professor Josef Marek - octogenarian
- Foregut diseases: foregut neoplasms