Molecular pathology of cholangiocellular carcinomas
Authors:
Libor Staněk 1,2,3; Robert Gürlich 1; Jan Hajer 4; Martin Oliverius 1; Renata Soumarová 5 5
Authors place of work:
Chirurgická klinika 3. LF UK a FN Královské Vinohrady, Praha
1; Ústav histologie a embryologie 1. LF UK v Praze
2; Vysoká škola zdravotnictví a sociální práce sv. Alžběty v Bratislavě
3; 2. interní klinika 3. LF UK a FN Královské Vinohrady, Praha
4; Onkologická klinika 3. LF UK a FN Královské Vinohrady, Praha
5
Published in the journal:
Čas. Lék. čes. 2019; 158: 64-67
Category:
Review Article
Summary
Cholangiocellular carcinoma is a relatively rare malignant tumor, originating from cholangiocytes, with poor prognosis and late diagnosis. It is a malignancy with a variable biological etiology, numerous genetic and epigenetic changes. Its incidence in the Czech Republic is about 1.4 per 100,000 people per year.
For good prognosis and long-term survival, early diagnosis with surgical treatment is important. In these cases, a 5-year survival rate is about 20-40 %. In the early diagnosis imaging methods and histopathological verification play an essential role, whereas laboratory oncomarkers are not yet sufficiently accurate. The same applies for genetic markers. This leads to the search of new molecular targets and the high effort in the introduction of cytological and molecular-biological methods with high specificity and sensitivity into routine practice. Current early diagnosis is based on the use of efficient imaging methods.
The use of genetic testing, and especially knowledge of the molecular basis of this disease, will be of a great benefit. The observation of the association between the genetic pathways, IDH1, RAS-MAPK etc., and genetic mutations of genes, such as TP53, KRAS, SMAD4, BRAF, IDH1/2, may be significant. From the molecular point of view, it is also interesting to monitor oncogenic potential in HBV/HCV infection.
Keywords:
cholangiocellular carcinoma – oncomarkers – mutation of genes – KRAS – p53
Zdroje
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Štítky
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistČlánok vyšiel v časopise
Journal of Czech Physicians
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Najčítanejšie v tomto čísle
- Surgery for cholangiocarcinoma
- Pathology of cholangiocellular carcinoma
- Artificial intelligence and modern information and communication technologies entering medicine
- Epidemiology of gallbladder and bile duct malignancies in the Czech Republic