Development of an in vitro model to study the effect of hyperbaric oxygen therapy on the antimicrobial effects of selected antibiotics

Česká verzia

Authors: M. Rozložník ^1,2,3; S. Havliková ¹; J. Kociánová ¹; M. Hájek ^1,4; A. Lochmanová ^1,5; B. Balcarková ¹; J. Kuzma ¹; D. Chmelař ¹
Authors place of work: Katedra biomedicínských oborů, Lékařská fakulta Ostravské univerzity, Ostrava, vedoucí katedry prof. MUDr. David Stejskal, Ph. D., MBA ¹; DNB consult, s. r. o, Kežmarok, vedoucí pracoviště Dr. Miroslav Rozložník ²; DAN Europe Slovensko, město ³; Městská nemocnice, Ostrava, MUDr. Petr Uhlig ⁴; Institut ochrany veřejného zdraví, Ostrava ⁵
Published in the journal: Pracov. Lék., 70, 2018, No. 3-4, s. 156-158.
Category:

Summary

Bacterial soft tissue infections represent the most common infections. Usually, they are caused by anaerobic, microaerophilic, facultative anaerobic and aerobic bacteria. In pathogenesis, a tissue is initially colonized by aerobic bacteria, which create a suitable environment for secondary colonization of anaerobic bacterial strains. Successful therapy of soft tissues infections consist of appropriate surgery treatment, targeted anti-microbial therapy and application of hyperbaric oxygen therapy (HBOT), i.e. breathing of pure oxygen under elevated ambient pressure. Nowadays, despite a lot of positive clinical evidence of HBOT in soft tissue infection treatment, no valid experimental model is established. The aim of our project was the development of an experimental model to study host-pathogen interaction during HBOT.

Keywords:

HBOT – antibiotics – Bacteria – hyperoxia

Zdroje

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