Pepsin and Weakly Acidic Esophageal Reflux
Authors:
Karol Zeleník
; P. Schwarz; M. Lázničková; Pavel Komínek
Authors place of work:
Klinika ORL FN Ostrava
přednosta doc. MUDr. P. Komínek, Ph. D., MBA
Published in the journal:
Otorinolaryngol Foniatr, 59, 2010, No. 3, pp. 124-128.
Category:
Original Article
Summary
Pepsin in weakly acid and slightly alkaline refluxes is considered to be main factor responsible for damage of hypopharyngeal and laryngeal epithelial cells. Its ability to stay stable and active also in weakly acid and slightly alkaline pH and its negative impact on epithelial cells are reasons, why some patients do not response even for aggressive antireflux therapy. Proper diagnosis of weakly acid and slightly alkaline refluxes is possible only with combination of pH-metry and multi-channel intraluminal impedance. Nowadays, pepsin inhibitors and pepsin receptor antagonists are developed to decrease negative impact of pepsin on laryngeal and hypopharyngeal epithelial cells in future.
Key words:
extraesophageal reflux, weakly acid reflux, pepsin, esophageal impedance.
Zdroje
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Štítky
Audiology Paediatric ENT ENT (Otorhinolaryngology)Článok vyšiel v časopise
Otorhinolaryngology and Phoniatrics
2010 Číslo 3
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