Colorectal Malignancies with Respect to Hemocoagulation

Česká verzia

Authors: M. Mýtnik; P. Kubisz ^*; J. Staško ^*; P. Šeliga; J. Daňo
Authors place of work: Chirurgická klinika FNsP Prešov, Slovenská republika, prednosta: MUDr. Miroslav Mýtnik, Ph. D. ; Národné centrum pre hemostázu a trombózu, MFN Martin, Slovenská republika prednosta: prof. MUDr. Peter Kubisz, DrSc. ^*
Published in the journal: Rozhl. Chir., 2009, roč. 88, č. 12, s. 735-739.
Category: Monothematic special - Original

Summary

Aim:
Relationship between malignants tumors and damage of hemocoagulation is known. The aim is analyse this damage and evaluate the thrombotic markers.

Material and methodics:
Authors analyses group of 137 patients with colorectal malignants tumors. They notifyes to relationship between plasmatic preoperative D dimer, PAI-1, F 1+2, Protein C level with controll group.

Results:
Especially aggressive forms of colorectal tumours have increased levels of D dimer and PAI-1. Protrombin fragments 1+2 were enhanced in the course of anastomotic dehiscence. Protein C level was reduced in 6.–7. decade and in advanced clinical stage.

Conclusion:
Praeoperative thrombotic markers assays inform about risk of thrombosis and clinical diseases stage. They prefere miniinvasive operations procedures. The maximall validity provides D dimer and PAI-1.

Key words:
colorectal malignant tumour – hypercoagulability – clinical stage

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